Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050902-05
Application #
2151989
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1991-07-01
Project End
1999-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Biochemistry
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Mahnke, Donna K; Sabina, Richard L (2005) Calcium activates erythrocyte AMP deaminase [isoform E (AMPD3)] through a protein-protein interaction between calmodulin and the N-terminal domain of the AMPD3 polypeptide. Biochemistry 44:5551-9
Haas, Amy Louise; Sabina, Richard L (2003) N-terminal extensions of the human AMPD2 polypeptide influence ATP regulation of isoform L. Biochem Biophys Res Commun 305:421-7
Haas, Amy Louise; Sabina, Richard L (2003) Expression, purification, and inhibition of in vitro proteolysis of human AMPD2 (isoform L) recombinant enzymes. Protein Expr Purif 27:293-303
Mahnke-Zizelman, Donna K; Sabina, Richard L (2002) N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform E. J Biol Chem 277:42654-62
Gross, M; Rotzer, E; Kolle, P et al. (2002) A G468-T AMPD1 mutant allele contributes to the high incidence of myoadenylate deaminase deficiency in the Caucasian population. Neuromuscul Disord 12:558-65
Mahnke-Zizelman, D K; Sabina, R L (2001) Localization of N-terminal sequences in human AMP deaminase isoforms that influence contractile protein binding. Biochem Biophys Res Commun 285:489-95
Norman, B; Sabina, R L; Jansson, E (2001) Regulation of skeletal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects. J Appl Physiol 91:258-64
Mahnke-Zizelman, D K; Tullson, P C; Sabina, R L (1998) Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms. J Biol Chem 273:35118-25
Sims, B; Powers, R E; Sabina, R L et al. (1998) Elevated adenosine monophosphate deaminase activity in Alzheimer's disease brain. Neurobiol Aging 19:385-91
Norman, B; Mahnke-Zizelman, D K; Vallis, A et al. (1998) Genetic and other determinants of AMP deaminase activity in healthy adult skeletal muscle. J Appl Physiol 85:1273-8

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