Arf Proteins in Insulin Signaling

Romero, Guillermo G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 3R01DK051183-02S1
• Application #: 2632812
• Study Section: Pharmacology A Study Section (PHRA)
• Project Start: 1996-06-01
• Project End: 1999-05-31
• Budget Start: 1997-06-30
• Budget End: 1998-05-31
• Support Year: 2
• Fiscal Year: 1997

Institution

• Name: University of Pittsburgh
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 053785812
• City: Pittsburgh
• State: PA
• Country: United States
• Zip Code: 15213

Publications

Andresen, Bradley T; Romero, Guillermo G; Jackson, Edwin K (2004) AT2 receptors attenuate AT1 receptor-induced phospholipase D activation in vascular smooth muscle cells. J Pharmacol Exp Ther 309:425-31

Andresen, Bradley T; Linnoila, Jenny J; Jackson, Edwin K et al. (2003) Role of EGFR transactivation in angiotensin II signaling to extracellular regulated kinase in preglomerular smooth muscle cells. Hypertension 41:781-6

Li, Hai-Sheng; Shome, Kuntala; Rojas, Raul et al. (2003) The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin. BMC Cell Biol 4:13

Pathre, Purnima; Shome, Kuntala; Blumental-Perry, Anna et al. (2003) Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export. EMBO J 22:4059-69

Rizzo, M A; Kraft, C A; Watkins, S C et al. (2001) Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade. J Biol Chem 276:34928-33

Andresen, B T; Jackson, E K; Romero, G G (2001) Angiotensin II signaling to phospholipase D in renal microvascular smooth muscle cells in SHR. Hypertension 37:635-9

Shome, K; Rizzo, M A; Vasudevan, C et al. (2000) The activation of phospholipase D by endothelin-1, angiotensin II, and platelet-derived growth factor in vascular smooth muscle A10 cells is mediated by small G proteins of the ADP-ribosylation factor family. Endocrinology 141:2200-8

Rizzo, M A; Shome, K; Vasudevan, C et al. (1999) Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem 274:1131-9

Shome, K; Nie, Y; Romero, G (1998) ADP-ribosylation factor proteins mediate agonist-induced activation of phospholipase D. J Biol Chem 273:30836-41

Rizzo, M A; Romero, G (1998) The role of G proteins in insulin signalling. J Basic Clin Physiol Pharmacol 9:167-95