Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
1R01DK051391-01
Application #
2152467
Study Section
Special Emphasis Panel (SRC (07))
Project Start
1996-05-01
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Shi, Shujie; Mutchler, Stephanie M; Blobner, Brandon M et al. (2018) Pore-lining residues of MEC-4 and MEC-10 channel subunits tune the Caenorhabditis elegans degenerin channel's response to shear stress. J Biol Chem 293:10757-10766
Ray, Evan C; Miller, Rachel G; Demko, John E et al. (2018) Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension. Kidney Int Rep 3:1434-1442
Buck, Teresa M; Jordahl, Alexa S; Yates, Megan E et al. (2017) Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Biochem J 474:357-376
Shi, Shujie; Buck, Teresa M; Kinlough, Carol L et al. (2017) Regulation of the epithelial Na+ channel by paraoxonase-2. J Biol Chem 292:15927-15938
Shi, Shujie; Luke, Cliff J; Miedel, Mark T et al. (2016) Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit. J Biol Chem 291:14012-22
Kashlan, Ossama B; Blobner, Brandon M; Zuzek, Zachary et al. (2015) Na+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleft. J Biol Chem 290:568-76
Heidrich, Elisa; Carattino, Marcelo D; Hughey, Rebecca P et al. (2015) Intracellular Na+ regulates epithelial Na+ channel maturation. J Biol Chem 290:11569-77
Chen, Jingxin; Kleyman, Thomas R; Sheng, Shaohu (2014) Deletion of ?-subunit exon 11 of the epithelial Na+ channel reveals a regulatory module. Am J Physiol Renal Physiol 306:F561-7
Carrisoza-Gaytan, Rolando; Liu, Yu; Flores, Daniel et al. (2014) Effects of biomechanical forces on signaling in the cortical collecting duct (CCD). Am J Physiol Renal Physiol 307:F195-204
Wei, Yuan; Liao, Yi; Zavilowitz, Beth et al. (2014) Angiotensin II type 2 receptor regulates ROMK-like K? channel activity in the renal cortical collecting duct during high dietary K? adaptation. Am J Physiol Renal Physiol 307:F833-43

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