Overall goal of this project is to define the functional consequences of interactions between the protein tyrosine kinase receptor, c-Kit, and its ligand, stem cell factor (SCF) during development of T lymphocytes. The project aims to define the consequences of functional intercellular communication events mediated by c-Kit and SCF that are significant to the biology of organ-specific T lymphocyte development. Specifically, the investigator proposes as follows: 1) to determine the role of thymic stromal-derived stem cell factor in thymocyte and intestinal T-cell development, 2) to determine the role of intestinal epithelial cell-derived stem cell factor in intestinal T-cell development and 3) to determine if stem cell factor and interleukin 7 are redundant or synergistic cytokines for thymic and intestinal T-cell development.
| Laky, Karen; Lewis, Julia M; Tigelaar, Robert E et al. (2003) Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. J Immunol 170:4087-94 |
| Schramm, C M; Puddington, L; Yiamouyiannis, C A et al. (2000) Proinflammatory roles of T-cell receptor (TCR)gammadelta and TCRalphabeta lymphocytes in a murine model of asthma. Am J Respir Cell Mol Biol 22:218-25 |
| Laky, K; Lefrancois, L; Lingenheld, E G et al. (2000) Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med 191:1569-80 |
| Yiamouyiannis, C A; Schramm, C M; Puddington, L et al. (1999) Shifts in lung lymphocyte profiles correlate with the sequential development of acute allergic and chronic tolerant stages in a murine asthma model. Am J Pathol 154:1911-21 |
| Laky, K; Lefrancois, L; von Freeden-Jeffry, U et al. (1998) The role of IL-7 in thymic and extrathymic development of TCR gamma delta cells. J Immunol 161:707-13 |
