Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052005-06
Application #
6726901
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Program Officer
Malozowski, Saul N
Project Start
1997-09-30
Project End
2006-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
6
Fiscal Year
2004
Total Cost
$302,750
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Chattopadhyay, Naibedya; Espinosa-Jeffrey, Araceli; Tfelt-Hansen, Jacob et al. (2008) Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. J Neurosci Res 86:2159-67
Huang, Yun; Zhou, Yubin; Yang, Wei et al. (2007) Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. J Biol Chem 282:19000-10
Bianco, Suzy D C; Peng, Ji-Bin; Takanaga, Hitomi et al. (2007) Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 22:274-85
Bandyopadhyay, Sanghamitra; Jeong, Kyeong-Hoon; Hansen, Jacob Tfelt et al. (2007) Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons. J Neurosci Res 85:882-95
Chattopadhyay, Naibedya; Jeong, Kyeong-Hoon; Yano, Shozo et al. (2007) Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab 292:E523-32
Conigrave, Arthur D; Brown, Edward M (2006) Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol 291:G753-61
Yano, Shozo; Mentaverri, Romuald; Kanuparthi, Deepthi et al. (2005) Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology 146:2324-35
Tfelt-Hansen, Jacob; Ferreira, Ana; Yano, Shozo et al. (2005) Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells. Am J Physiol Endocrinol Metab 288:E1206-13
Mallya, Sanjay M; Gallagher, James J; Wild, Yvette K et al. (2005) Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol 19:2603-9
Tfelt-Hansen, Jacob; Yano, Shozo; John Macleod, R et al. (2005) High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors 23:117-23

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