Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052314-04
Application #
6517411
Study Section
General Medicine B Study Section (GMB)
Program Officer
Flessner, Michael Francis
Project Start
1999-05-01
Project End
2004-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
4
Fiscal Year
2002
Total Cost
$258,860
Indirect Cost

  Institution

Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903

  Publications

Gong, Rujun; Rifai, Abdalla; Ge, Yan et al. (2008) Hepatocyte growth factor suppresses proinflammatory NFkappaB activation through GSK3beta inactivation in renal tubular epithelial cells. J Biol Chem 283:7401-10
Gong, Rujun; Rifai, Abdalla; Dworkin, Lance D (2006) Anti-inflammatory effect of hepatocyte growth factor in chronic kidney disease: targeting the inflamed vascular endothelium. J Am Soc Nephrol 17:2464-73
Gong, R; Rifai, A; Dworkin, L D (2006) Hepatocyte growth factor suppresses acute renal inflammation by inhibition of endothelial E-selectin. Kidney Int 69:1166-74
Gong, Rujun; Rifai, Abdalla; Dworkin, Lance D (2005) Activation of PI3K-Akt-GSK3beta pathway mediates hepatocyte growth factor inhibition of RANTES expression in renal tubular epithelial cells. Biochem Biophys Res Commun 330:27-33
Biswas, Purba; Roy, Abinash; Gong, Rujun et al. (2005) Hepatocyte growth factor induces an endothelin-mediated decline in glomerular filtration rate. Am J Physiol Renal Physiol 288:F8-15
Gong, Rujun; Rifai, Abdalla; Tolbert, Evelyn M et al. (2004) Hepatocyte growth factor ameliorates renal interstitial inflammation in rat remnant kidney by modulating tubular expression of macrophage chemoattractant protein-1 and RANTES. J Am Soc Nephrol 15:2868-81
Dworkin, Lance D; Gong, Rujun; Tolbert, Evelyn et al. (2004) Hepatocyte growth factor ameliorates progression of interstitial fibrosis in rats with established renal injury. Kidney Int 65:409-19
Gong, Rujun; Rifai, Abdalla; Tolbert, Evelyn M et al. (2003) Hepatocyte growth factor modulates matrix metalloproteinases and plasminogen activator/plasmin proteolytic pathways in progressive renal interstitial fibrosis. J Am Soc Nephrol 14:3047-60
Rifai, A; Dworkin, L D; Chen, A (2001) Genomic approaches to elucidating the pathophysiology of renal diseases. Zhonghua Yi Xue Za Zhi (Taipei) 64:555-62
Liu, Y; Rajur, K; Tolbert, E et al. (2000) Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways. Kidney Int 58:2028-43