Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK052766-07
Application #
6712763
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
Hamilton, Frank A
Project Start
1997-09-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
7
Fiscal Year
2004
Total Cost
$289,080
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Treichel, Anthony J; Farrugia, Gianrico; Beyder, Arthur (2018) The touchy business of gastrointestinal (GI) mechanosensitivity. Brain Res 1693:197-200
Knutson, Katilyn; Strege, Peter R; Li, Joyce et al. (2018) Whole Cell Electrophysiology of Primary Cultured Murine Enterochromaffin Cells. J Vis Exp :
Strege, Peter R; Mazzone, Amelia; Bernard, Cheryl E et al. (2018) Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased NaV1.5 current and mechanosensitivity. Am J Physiol Gastrointest Liver Physiol 314:G494-G503
Alcaino, Constanza; Knutson, Kaitlyn R; Treichel, Anthony J et al. (2018) A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Proc Natl Acad Sci U S A 115:E7632-E7641
Strege, Peter R; Knutson, Kaitlyn; Eggers, Samuel J et al. (2017) Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release. Sci Rep 7:15650
Alcaino, C; Farrugia, G; Beyder, A (2017) Mechanosensitive Piezo Channels in the Gastrointestinal Tract. Curr Top Membr 79:219-244
Wang, Fan; Knutson, Kaitlyn; Alcaino, Constanza et al. (2017) Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces. J Physiol 595:79-91
Beyder, Arthur; Farrugia, Gianrico (2016) Ion channelopathies in functional GI disorders. Am J Physiol Gastrointest Liver Physiol 311:G581-G586
Beyder, A; Gibbons, S J; Mazzone, A et al. (2016) Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum. Neurogastroenterol Motil 28:64-73
Neshatian, Leila; Strege, Peter R; Rhee, Poong-Lyul et al. (2015) Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells. Am J Physiol Gastrointest Liver Physiol 309:G506-12

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