Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK053673-03
Application #
2906168
Study Section
Special Emphasis Panel (ZHL1-CSR-J (M1))
Program Officer
Badman, David G
Project Start
1997-09-01
Project End
2001-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Melikova, Sofya; Dylla, Scott J; Verfaillie, Catherine M (2004) Phosphatidylinositol-3-kinase activation mediates proline-rich tyrosine kinase 2 phosphorylation and recruitment to beta1-integrins in human CD34+ cells. Exp Hematol 32:1051-6
Salesse, S; Dylla, S J; Verfaillie, C M (2004) p210BCR/ABL-induced alteration of pre-mRNA splicing in primary human CD34+ hematopoietic progenitor cells. Leukemia 18:727-33
Dylla, Scott J; Deyle, David R; Theunissen, Koen et al. (2004) Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene products. Exp Hematol 32:365-74
Lewis, I D; Almeida-Porada, G; Du, J et al. (2001) Umbilical cord blood cells capable of engrafting in primary, secondary, and tertiary xenogeneic hosts are preserved after ex vivo culture in a noncontact system. Blood 97:3441-9
Zhao, R C; Jiang, Y; Verfaillie, C M (2001) A model of human p210(bcr/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR/ABL-containing retroviral vector. Blood 97:2406-12
Prosper, F; Verfaillie, C M (2001) Regulation of hematopoiesis through adhesion receptors. J Leukoc Biol 69:307-16
Jiang, Y; Prosper, F; Verfaillie, C M (2000) Opposing effects of engagement of integrins and stimulation of cytokine receptors on cell cycle progression of normal human hematopoietic progenitors. Blood 95:846-54
Jiang, Y; Zhao, R C; Verfaillie, C M (2000) Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34+ cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27Kip, which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity. Proc Natl Acad Sci U S A 97:10538-43
Verfaillie, C M; Almeida-Porada, G; Wissink, S et al. (2000) Kinetics of engraftment of CD34(-) and CD34(+) cells from mobilized blood differs from that of CD34(-) and CD34(+) cells from bone marrow. Exp Hematol 28:1071-9
Prosper, F; Stroncek, D; McCarthy, J B et al. (1998) Mobilization and homing of peripheral blood progenitors is related to reversible downregulation of alpha4 beta1 integrin expression and function. J Clin Invest 101:2456-67