Abstract

This is a proposal to characterize the adrenocortical adaptation to hypoxia in the perinatal period.
In specific aims 1 -3, the adaptation to and recovery from pre- and postnatal hypoxia in the neonatal and juvenile rat will be studied by measuring plasma hormone concentrations and electrolytes, aldosteroidogenesis in vitro, the expression of steroidogenic enzyme mRNA's, and mitochondrial histomorphometry.
Specific aim 4 will determine if increased ACTH is a major mechanism in the adaptation of the aldosteroidogenic pathway to hypoxia in the neonatal rat.
Specific aim 5 will determine if the dramatic changes in plasma lipids which occur in the hypoxic, suckling rat, are a major influence on aldosteroidogenesis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK054685-03
Application #
6342526
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Sato, Sheryl M
Project Start
1999-01-01
Project End
2002-12-31
Budget Start
2001-01-01
Budget End
2001-12-31
Support Year
3
Fiscal Year
2001
Total Cost
$144,972
Indirect Cost

  Institution

Name
Medical College of Wisconsin
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226

  Publications

Bruder, Eric D; Taylor, Jennifer K; Kamer, Kimberli J et al. (2008) Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Am J Physiol Regul Integr Comp Physiol 295:R1195-203
Bruder, E D; Hoof, J Van; Young, J B et al. (2008) Epidermal growth factor and parathyroid hormone-related peptide mRNA in the mammary gland and their concentrations in milk: effects of postpartum hypoxia in lactating rats. Horm Metab Res 40:446-53
Raff, H; Jacobson, L; Cullinan, W E (2007) Augmented hypothalamic corticotrophin-releasing hormone mRNA and corticosterone responses to stress in adult rats exposed to perinatal hypoxia. J Neuroendocrinol 19:907-12
Raff, Hershel; Jacobson, Lauren (2007) Glucocorticoid feedback control of corticotropin in the hypoxic neonatal rat. J Endocrinol 192:453-8
Bruder, Eric D; Lee, Julie J; Widmaier, Eric P et al. (2007) Microarray and real-time PCR analysis of adrenal gland gene expression in the 7-day-old rat: effects of hypoxia from birth. Physiol Genomics 29:193-200
Bruder, E D; Henderson, L M; Raff, H (2006) Adrenal lipid profiles of chemically sympathectomized normoxic and hypoxic neonatal rats. Horm Metab Res 38:807-11
Raff, Hershel; Bruder, Eric D (2006) Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia. Endocrine 29:341-4
Bruder, Eric D; Jacobson, Lauren; Raff, Hershel (2005) Plasma leptin and ghrelin in the neonatal rat: interaction of dexamethasone and hypoxia. J Endocrinol 185:477-84
Bruder, Eric D; Lee, Ping C; Raff, Hershel (2005) Lipid and fatty acid profiles in the brain, liver, and stomach contents of neonatal rats: effects of hypoxia. Am J Physiol Endocrinol Metab 288:E314-20
Bruder, Eric D; Lee, Ping C; Raff, Hershel (2004) Metabolic consequences of hypoxia from birth and dexamethasone treatment in the neonatal rat: comprehensive hepatic lipid and fatty acid profiling. Endocrinology 145:5364-72

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