Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK057840-03
Application #
6517773
Study Section
General Medicine A Subcommittee 2 (GMA)
Program Officer
May, Michael K
Project Start
2000-07-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
3
Fiscal Year
2002
Total Cost
$217,760
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Surgery
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Fichna, J; Poole, D P; Veldhuis, N et al. (2015) Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. J Mol Med (Berl) 93:1297-309
Pelayo, Juan-Carlos; Veldhuis, Nicholas A; Eriksson, Emily M et al. (2014) Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon. Cell Tissue Res 356:319-32
Haerteis, Silke; Krappitz, Annabel; Krappitz, Matteus et al. (2014) Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. J Biol Chem 289:19067-78
Poole, Daniel P; Amadesi, Silvia; Veldhuis, Nicholas A et al. (2013) Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. J Biol Chem 288:5790-802
Alemi, Farzad; Kwon, Edwin; Poole, Daniel P et al. (2013) The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest 123:1513-30
Alemi, Farzad; Poole, Daniel P; Chiu, Jonathan et al. (2013) The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144:145-54
Veldhuis, Nicholas A; Lew, Michael J; Abogadie, Fe C et al. (2012) N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor. J Biol Chem 287:21765-72
Haerteis, Silke; Krappitz, Matteus; Bertog, Marko et al. (2012) Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S. Pflugers Arch 464:353-65
Hasdemir, Burcu; Mahajan, Shilpi; Bunnett, Nigel W et al. (2012) Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol 26:681-95
Lyo, Victoria; Cattaruzza, Fiore; Kim, Tyson N et al. (2012) Active cathepsins B, L, and S in murine and human pancreatitis. Am J Physiol Gastrointest Liver Physiol 303:G894-903

Showing the most recent 10 out of 48 publications