Glucuronidation of Fatty Acids by Human ER &Nuclear UGT

Radominska-Pandya, Anna

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK060109-03
• Application #: 6787636
• Study Section: Special Emphasis Panel (ZRG1-PTHA (01))
• Program Officer: Serrano, Jose
• Project Start: 2002-08-15
• Project End: 2006-05-31
• Budget Start: 2004-06-01
• Budget End: 2005-05-31
• Support Year: 3
• Fiscal Year: 2004
• Total Cost: $275,126

Institution

• Name: University of Arkansas for Medical Sciences
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 122452563
• City: Little Rock
• State: AR
• Country: United States
• Zip Code: 72205

Publications

Mazur, Anna; Lichti, Cheryl F; Prather, Paul L et al. (2009) Characterization of human hepatic and extrahepatic UDP-glucuronosyltransferase enzymes involved in the metabolism of classic cannabinoids. Drug Metab Dispos 37:1496-504

Itäaho, Katriina; Court, Michael H; Uutela, Päivi et al. (2009) Dopamine is a low-affinity and high-specificity substrate for the human UDP-glucuronosyltransferase 1A10. Drug Metab Dispos 37:768-75

Miller, Grover P; Lichti, Cheryl F; Zielinska, Agnieszka K et al. (2008) Identification of hydroxywarfarin binding site in human UDP glucuronosyltransferase 1a10: phenylalanine90 is crucial for the glucuronidation of 6- and 7-hydroxywarfarin but not 8-hydroxywarfarin. Drug Metab Dispos 36:2211-8

Starlard-Davenport, Athena; Lyn-Cook, Beverly; Radominska-Pandya, Anna (2008) Identification of UDP-glucuronosyltransferase 1A10 in non-malignant and malignant human breast tissues. Steroids 73:611-20

Xiong, Yan; Patana, Anne-Sisko; Miley, Michael J et al. (2008) The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis. Drug Metab Dispos 36:517-22

Lu, Yuan; Bratton, Stacie; Heydel, Jean-Marie et al. (2008) Effect of retinoids on UDP-glucuronosyltransferase 2B7 mRNA expression in Caco-2 cells. Drug Metab Pharmacokinet 23:364-72

Starlard-Davenport, Athena; Lyn-Cook, Beverly; Radominska-Pandya, Anna (2008) Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene. Steroids 73:139-47

Zielinska, Agnieszka; Lichti, Cheryl F; Bratton, Stacie et al. (2008) Glucuronidation of monohydroxylated warfarin metabolites by human liver microsomes and human recombinant UDP-glucuronosyltransferases. J Pharmacol Exp Ther 324:139-48

Miley, Michael J; Zielinska, Agnieszka K; Keenan, Jeffrey E et al. (2007) Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. J Mol Biol 369:498-511

Starlard-Davenport, Athena; Xiong, Yan; Bratton, Stacie et al. (2007) Phenylalanine(90) and phenylalanine(93) are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10. Steroids 72:85-94