Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK063212-02
Application #
6692589
Study Section
Reproductive Endocrinology Study Section (REN)
Program Officer
Margolis, Ronald N
Project Start
2003-02-01
Project End
2007-01-31
Budget Start
2004-02-01
Budget End
2005-01-31
Support Year
2
Fiscal Year
2004
Total Cost
$370,125
Indirect Cost
Name
University of Rochester
Department
Pathology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Yan, Shian-Jang; Lee, Yi-Fen; Ting, Huei-Ju et al. (2012) Deficiency in TR4 nuclear receptor abrogates Gadd45a expression and increases cytotoxicity induced by ionizing radiation. Cell Mol Biol Lett 17:309-22
Collins, Loretta L; Lee, Yi-Fen; Ting, Huei-Ju et al. (2011) The roles of testicular nuclear receptor 4 (TR4) in male fertility-priapism and sexual behavior defects in TR4 knockout mice. Reprod Biol Endocrinol 9:138
Lee, Yi-Fen; Liu, Su; Liu, Ning-Chun et al. (2011) Premature aging with impaired oxidative stress defense in mice lacking TR4. Am J Physiol Endocrinol Metab 301:E91-8
Chen, Yei-Tsung; Collins, Loretta L; Chang, Shu-Shi et al. (2008) The roles of testicular orphan nuclear receptor 4 (TR4) in cerebellar development. Cerebellum 7:9-17
Kim, Eungseok; Ma, Wen-Lung; Lin, Din-Lii et al. (2007) TR4 orphan nuclear receptor functions as an apoptosis modulator via regulation of Bcl-2 gene expression. Biochem Biophys Res Commun 361:323-8
Zhang, Yanqing; Chen, Yei-Tsung; Xie, Shaozhen et al. (2007) Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain. Mol Endocrinol 21:908-20
Chen, Yei-Tsung; Collins, Loretta L; Uno, Hideo et al. (2007) Abnormal cerebellar cytoarchitecture and impaired inhibitory signaling in adult mice lacking TR4 orphan nuclear receptor. Brain Res 1168:72-82
Chen, Yei-Tsung; Collins, Loretta L; Uno, Hideo et al. (2005) Deficits in motor coordination with aberrant cerebellar development in mice lacking testicular orphan nuclear receptor 4. Mol Cell Biol 25:2722-32
Mu, Xiaomin; Lee, Yi-Fen; Liu, Ning-Chun et al. (2004) Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol Cell Biol 24:5887-99
Collins, Loretta L; Lee, Yi-Fen; Heinlein, Cynthia A et al. (2004) Growth retardation and abnormal maternal behavior in mice lacking testicular orphan nuclear receptor 4. Proc Natl Acad Sci U S A 101:15058-63

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