Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK063930-34
Application #
6823252
Study Section
Orthopedics and Musculoskeletal Study Section (ORTH)
Program Officer
Malozowski, Saul N
Project Start
1975-01-01
Project End
2007-12-31
Budget Start
2005-01-01
Budget End
2005-12-31
Support Year
34
Fiscal Year
2005
Total Cost
$378,750
Indirect Cost

  Institution

Name
University of Arizona
Department
Biochemistry
Type
Schools of Medicine
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

Bartik, Leonid; Whitfield, G Kerr; Kaczmarska, Magdalena et al. (2010) Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem 21:1153-61
Haussler, Mark R; Haussler, Carol A; Whitfield, G Kerr et al. (2010) The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the ""Fountain of Youth"" to mediate healthful aging. J Steroid Biochem Mol Biol 121:88-97
Hsieh, Jui-Cheng; Slater, Stephanie A; Whitfield, G Kerr et al. (2010) Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle. J Cell Biochem 110:671-86
Haussler, Mark R; Haussler, Carol A; Bartik, Leonid et al. (2008) Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention. Nutr Rev 66:S98-112
Jurutka, Peter W; Bartik, Leonid; Whitfield, G Kerr et al. (2007) Vitamin D receptor: key roles in bone mineral pathophysiology, molecular mechanism of action, and novel nutritional ligands. J Bone Miner Res 22 Suppl 2:V2-10
Barthel, Thomas K; Mathern, Douglas R; Whitfield, G Kerr et al. (2007) 1,25-Dihydroxyvitamin D3/VDR-mediated induction of FGF23 as well as transcriptional control of other bone anabolic and catabolic genes that orchestrate the regulation of phosphate and calcium mineral metabolism. J Steroid Biochem Mol Biol 103:381-8
Jurutka, Peter W; Thompson, Paul D; Whitfield, G Kerr et al. (2005) Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4. J Cell Biochem 94:917-43
Hsieh, Jui-Cheng; Whitfield, G Kerr; Jurutka, Peter W et al. (2003) Two basic amino acids C-terminal of the proximal box specify functional binding of the vitamin D receptor to its rat osteocalcin deoxyribonucleic acid-responsive element. Endocrinology 144:5065-80
Hsieh, Jui-Cheng; Sisk, Jeanne M; Jurutka, Peter W et al. (2003) Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. J Biol Chem 278:38665-74