As reductionist biomedical science succeeds in elucidating ever more detail at the molecular level, a mathematical modeling framework will become increasingly important to cope with this explosion of data and to relate integrated whole organ function to underlying biophysically detailed mechanisms that exploit this molecular knowledge. The proposed research has two primary long term objectives. The first is to develop an extensible anatomically and biophysically based modeling framework that can be used to integrate the physiological, anatomical and medical knowledge of the gastrointestinal (GI) system. The second objective is to focus this integrative modeling framework on two major diseases of the GI tract which affect a significant number of people in the United States, namely intestinal ischemia and diabetic gastroparesis. Prior research has shown that recordings of the magnetic field from gastrointestinal electrical activity using multichannel Superconducting QUantum Interference Device (SQUID) magnetometers provides a noninvasive, noncontact assessment of the physiological state of the GI smooth muscle. We will combine multichannel SQUID and cutaneous electrode measurements with anatomically based integrative computer models to investigate the inter- and intra-subject effects of intestinal ischemia and gastroparesis on GI electrical activity noninvasively. We hypothesize that the resulting integration of anatomical and physiological biophysical properties will serve as a basis for a more complete understanding of the gastrointestinal system and will aid in the detection and diagnosis and ultimately, in the treatment of gastrointestinal disorders. This is necessarily a collaborative project that initially involves four groups (the Living State Physics Group at Vanderbilt University, The Department of Surgery at Vanderbilt University, the Department of Physiology and Cell Biology, University of Nevada School of Medicine and the Bioengineering Institute at The University of Auckland) and combines expertise in integrated biophysically based modeling with physiological, clinical and research expertise in the function of the gastrointestinal system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK064775-05
Application #
7425869
Study Section
Special Emphasis Panel (ZRG1-SSS-X (10))
Program Officer
Hamilton, Frank A
Project Start
2004-06-01
Project End
2010-07-31
Budget Start
2008-06-01
Budget End
2010-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$240,792
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Surgery
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Mayne, Terence P; Paskaranandavadivel, Niranchan; Erickson, Jonathan C et al. (2018) Improved Visualization of Gastrointestinal Slow Wave Propagation Using a Novel Wavefront-Orientation Interpolation Technique. IEEE Trans Biomed Eng 65:319-326
Paskaranandavadivel, Niranchan; OGrady, Gregory; Cheng, Leo K (2017) Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity. IEEE Trans Biomed Eng 64:166-172
Angeli, T R; Du, P; Paskaranandavadivel, N et al. (2017) High-resolution electrical mapping of porcine gastric slow-wave propagation from the mucosal surface. Neurogastroenterol Motil 29:
Berry, Rachel; Paskaranandavadivel, Niranchan; Du, Peng et al. (2017) A novel retractable laparoscopic device for mapping gastrointestinal slow wave propagation patterns. Surg Endosc 31:477-486
Zifan, Ali; Kumar, Dushyant; Cheng, Leo K et al. (2017) Three-Dimensional Myoarchitecture of the Lower Esophageal Sphincter and Esophageal Hiatus Using Optical Sectioning Microscopy. Sci Rep 7:13188
Du, Peng; Calder, Stefan; Angeli, Timothy R et al. (2017) Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities. Front Physiol 8:1136
Lin, Anthony Y; Du, Peng; Dinning, Philip G et al. (2017) High-resolution anatomic correlation of cyclic motor patterns in the human colon: Evidence of a rectosigmoid brake. Am J Physiol Gastrointest Liver Physiol 312:G508-G515
Du, Peng; Paskaranandavadivel, Niranchan; Angeli, Timothy R et al. (2016) The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications. Wiley Interdiscip Rev Syst Biol Med 8:69-85
Berry, Rachel; Miyagawa, Taimei; Paskaranandavadivel, Niranchan et al. (2016) Functional physiology of the human terminal antrum defined by high-resolution electrical mapping and computational modeling. Am J Physiol Gastrointest Liver Physiol 311:G895-G902
Erickson, Jonathan C; Putney, Joy; Hilbert, Douglas et al. (2016) Iterative Covariance-Based Removal of Time-Synchronous Artifacts: Application to Gastrointestinal Electrical Recordings. IEEE Trans Biomed Eng 63:2262-2272

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