Both type 1 and 2 diabetes are caused by inadequate insulin secretion, and in both diseases this can be ascribed in large part to loss of pancreatic ?-cells that produce insulin. Both diseases can be cured by replacement of pancreatic ?-cells by pancreas transplantation but this requires life-long immunosuppression and there are far fewer organ donors than people with diabetes. An alternative approach to restoring pancreatic ?-cells is to foster regeneration of ?-cells in the patient. Recent studies in mice have provided important insights into how ?-cells are formed and their number increased and maintained after birth. Complementary studies in humans are few because of the difficulty in obtaining appropriate material and the difficulty of undertaking lineage tracing studies in humans.
Both type 1 and 2 diabetes are caused by inadequate insulin secretion; and in both diseases this can be ascribed in large part to loss of pancreatic ?-cells that produce insulin. Both diseases can be cured by replacement of pancreatic ?-cells by pancreas transplantation but this requires life-long immunosuppression and there are far fewer organ donors than people with diabetes. An alternative approach is to foster regeneration of ?-cells in the patient him/herself; and the basis of this grant is to explore an approach to that end
| Butler, Alexandra E; Sacks, Wendy; Rizza, Robert A et al. (2017) Down Syndrome-Associated Diabetes Is Not Due To a Congenital Deficiency in ? Cells. J Endocr Soc 1:39-45 |
| Moin, Abu Saleh Md; Butler, Peter C; Butler, Alexandra E (2017) Increased Proliferation of the Pancreatic Duct Gland Compartment in Type 1 Diabetes. J Clin Endocrinol Metab 102:200-209 |
| Md Moin, Abu Saleh; Cory, Megan; Ong, Allison et al. (2017) Pancreatic Nonhormone Expressing Endocrine Cells in Children With Type 1 Diabetes. J Endocr Soc 1:385-395 |
| Schludi, Belinda; Moin, Abu Saleh Md; Montemurro, Chiara et al. (2017) Islet inflammation and ductal proliferation may be linked to increased pancreatitis risk in type 2 diabetes. JCI Insight 2: |
| Montemurro, Chiara; Vadrevu, Suryakiran; Gurlo, Tatyana et al. (2017) Cell cycle-related metabolism and mitochondrial dynamics in a replication-competent pancreatic beta-cell line. Cell Cycle 16:2086-2099 |
| Butler, Alexandra E; Dhawan, Sangeeta; Hoang, Jonathan et al. (2016) ?-Cell Deficit in Obese Type 2 Diabetes, a Minor Role of ?-Cell Dedifferentiation and Degranulation. J Clin Endocrinol Metab 101:523-32 |
| Butler, Alexandra E; Matveyenko, Aleksey V; Kirakossian, David et al. (2016) Recovery of high-quality RNA from laser capture microdissected human and rodent pancreas. J Histotechnol 39:59-65 |
| Gurlo, Tatyana; Butler, Peter C; Butler, Alexandra E (2016) Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue. J Histotechnol 39:8-16 |
| Md Moin, Abu Saleh; Dhawan, Sangeeta; Cory, Megan et al. (2016) Increased Frequency of Hormone Negative and Polyhormonal Endocrine Cells in Lean Individuals With Type 2 Diabetes. J Clin Endocrinol Metab 101:3628-3636 |
| Md Moin, Abu Saleh; Dhawan, Sangeeta; Shieh, Christine et al. (2016) Increased Hormone-Negative Endocrine Cells in the Pancreas in Type 1 Diabetes. J Clin Endocrinol Metab 101:3487-96 |
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