A diagnostic X-ray imaging system is required to simultaneously have high contrast, high resolution and be fast with low dose to the patient. High contrast and low dose requirements are of a particular interest in mammography, where low contrast tumors and microcalcifications are to be detected at high scatter levels. The limitations of the currently scanning slot systems include the inherently high noise level of the CCD, suboptimal conversion efficiency, limited charge capacity of the CCD and its relatively high scatter fraction (up to 20%) due to its wide scanning slot. The purpose of this project is to develop a scanning multi-slit X-ray imaging system based on an """"""""edge-on"""""""" illuminated microchannel plate (MCP) detector for potential application in mammography. The advantages of an """"""""edge-on"""""""" MCP detector over other types of X-ray detectors are the possibility to combine high stopping power, superior spatial resolution, direct energy-tocharge conversion, high physical charge amplification and very low noise. More specifically, the aims are: (1) Design and development of a scanning slit X-ray imaging system based on """"""""edge-on"""""""" MCP detector and delay line electronics for digital mammography. (2) Investigation of the hypothesis that an X-ray imaging system based on """"""""edge-on"""""""" MCP detector can offer substantially improved detection quantum efficiency, resolution, noise and scatter fraction as compared to other currently available mammography systems. (3) Design and development of chip level application specific integrated circuit (ASIC) electronics with very highcount rate capability. (4) Development and evaluation of a clinically applicable single slit prototype X-ray imaging system based on """"""""edge-on"""""""" MCP detector with ASIC electronics. (5) Design of a clinically applicable multi-slit x-ray imaging system for digital mammography. The proposed multi-slit X-ray imaging system based on an """"""""edge-on"""""""" MCP detector will be photon counting, quantum limited and low scatter fraction. It can potentially provide a high-resolution detector with significant reduction in patient dose for digital mammography.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB000514-03
Application #
6884583
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Haller, John W
Project Start
2003-07-01
Project End
2007-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
3
Fiscal Year
2005
Total Cost
$239,409
Indirect Cost
Name
University of California Irvine
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Kubicki, Marek; Shenton, Martha E (2014) Diffusion Tensor Imaging findings and their implications in schizophrenia. Curr Opin Psychiatry 27:179-84
Skup, Martha; Zhu, Hongtu; Zhang, Heping (2012) Multiscale adaptive marginal analysis of longitudinal neuroimaging data with time-varying covariates. Biometrics 68:1083-92
Ducote, Justin L; Molloi, Sabee (2008) Quantification of breast density with dual energy mammography: a simulation study. Med Phys 35:5411-8
Balestreire, Elena M; Apodaca, Gerard (2007) Apical epidermal growth factor receptor signaling: regulation of stretch-dependent exocytosis in bladder umbrella cells. Mol Biol Cell 18:1312-23
Apodaca, G; Balestreire, E; Birder, L A (2007) The uroepithelial-associated sensory web. Kidney Int 72:1057-64
Shikhaliev, Polad M; Xu, Tong; Molloi, Sabee (2005) Photon counting computed tomography: concept and initial results. Med Phys 32:427-36
Shikhaliev, Polad M; Xu, Tong; Le, Huy et al. (2004) Scanning-slit photon counting x-ray imaging system using a microchannel plate detector. Med Phys 31:1061-71