This project seeks to continue developing and maintaining a software application ITK-SNAP, which provides functionality for user-guided automatic segmentation and manual annotation of 3D volumes generated by biomedical imaging. ITK-SNAP is a free, open-source software tool that has a large number of users in the biomedical community (estimated in the thousands) and has contributed to over 200 publications since 2006, spanning a wide range of biomedical applications and imaging modalities. Furthermore, ITK-SNAP occupies a unique place in the spectrum of open-source tools available to today's imaging researcher, with a mature user interface and functionality specifically focused on the problem of image segmentation. The broad goals of this project are to ensure the long-term availability and viability of ITK-SNAP in the face of ever increasing complexity of imaging datasets and rapidly changing software environment;and to significantly expand the class of biomedical image segmentation problems that can benefit from the automatic features of ITK-SNAP.
Five specific aims are proposed to achieve these goals.
Aim 1 will develop a novel software framework for semi-automatic segmentation of multimodality and multichannel imaging data.
This aim will extend the existing active contour segmentation framework with a flexible toolbox for user-guided generation of object/background probability maps from image volumes. The toolbox will support texture analysis and pattern classification, as well as user-generated spatial segmentation priors.
Aim 2 will boost the performance of ITK-SNAP by employing graphics card acceleration and will change the internal data structures to allow the tool to work with very large image volumes, like those produced by high-resolution multi-slice CT or confocal microscopy.
Aim 3 will remove ITK-SNAP dependencies on an aging and poorly supported FLTK user interface software library, transitioning instead to the QT library, which has strong community and industry support.
This aim will also make critical improvements to ITK-SNAP usability, including support for the project paradigm.
In Aim 4, segmentation protocols based on new ITK-SNAP functionality will be developed to address a diverse set of biomedical image segmentation problems. These protocols will then be validated against manual segmentation using public datasets. The criterion for success is to achieve a two-fold or better reduction in segmentation time with no penalty in inter-observer or intra-observer reliability.
Aim 5 is to continue supporting the ITK-SNAP user community by implementing user-requested features, correcting defects in the software, and providing thorough documentation, including video tutorials, and training and outreach efforts.

Public Health Relevance

ITK-SNAP is an interactive software tool that simplifies and automates a difficult task faced by thousands of biomedical researchers: how to measure and quantify relevant structures in three-dimensional medical images like MRI and CT? ITK-SNAP has contributed to hundreds of published studies spanning many areas of research, including in key public health areas such as cancer, cardiovascular disorders, and brain disorders. If funded, this application will ensure that ITK-SNAP is available to researchers in the future, as well as implement innovations that will allow even more researchers to take advantage of the tool's automation capabilities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB014346-01
Application #
8222185
Study Section
Biodata Management and Analysis Study Section (BDMA)
Program Officer
Pai, Vinay Manjunath
Project Start
2011-09-19
Project End
2015-08-31
Budget Start
2011-09-19
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$518,337
Indirect Cost
Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Yushkevich, Paul A; Pashchinskiy, Artem; Oguz, Ipek et al. (2018) User-Guided Segmentation of Multi-modality Medical Imaging Datasets with ITK-SNAP. Neuroinformatics :
Wolk, David A; Das, Sandhitsu R; Mueller, Susanne G et al. (2017) Medial temporal lobe subregional morphometry using high resolution MRI in Alzheimer's disease. Neurobiol Aging 49:204-213
Yushkevich, Paul A; Yang Gao; Gerig, Guido (2016) ITK-SNAP: An interactive tool for semi-automatic segmentation of multi-modality biomedical images. Conf Proc IEEE Eng Med Biol Soc 2016:3342-3345
Contijoch, Francisco; Rogers, Kelly; Rears, Hannah et al. (2016) Quantification of Left Ventricular Function With Premature Ventricular Complexes Reveals Variable Hemodynamics. Circ Arrhythm Electrophysiol 9:e003520
Wisse, L E M; Kuijf, H J; Honingh, A M et al. (2016) Automated Hippocampal Subfield Segmentation at 7T MRI. AJNR Am J Neuroradiol 37:1050-7
Contijoch, Francisco; Witschey, Walter R T; Rogers, Kelly et al. (2016) Impact of end-diastolic and end-systolic phase selection in the volumetric evaluation of cardiac MRI. J Magn Reson Imaging 43:585-93
Pouch, Alison M; Tian, Sijie; Takabe, Manabu et al. (2015) Segmentation of the Aortic Valve Apparatus in 3D Echocardiographic Images: Deformable Modeling of a Branching Medial Structure. Stat Atlases Comput Models Heart 8896:196-203
Yushkevich, Paul A; Pluta, John B; Wang, Hongzhi et al. (2015) Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapp 36:258-87
Pouch, Alison M; Tian, Sijie; Takebe, Manabu et al. (2015) Medially constrained deformable modeling for segmentation of branching medial structures: Application to aortic valve segmentation and morphometry. Med Image Anal 26:217-31
Contijoch, Francisco; Witschey, Walter R T; Rogers, Kelly et al. (2015) User-initialized active contour segmentation and golden-angle real-time cardiovascular magnetic resonance enable accurate assessment of LV function in patients with sinus rhythm and arrhythmias. J Cardiovasc Magn Reson 17:37

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