Optimal integration of MRI in Radiation Oncology is hindered by the lack of methods that harvest the significant prior knowledge available to sample the anatomy, biological status, and physiologic motions of individual patients. While some generic image acquisition methods take advantage of non-specific low rank structure of human MR signals to achieve some modest acceleration, the wealth of specific prior knowledge, from both the population of similar patients as well as the specific patient, has yet to be effectively tapped to guide optimal treatment planning, positioning, and monitoring. We hypothesize that biological, morphological, and motion models of the patient can be accurately derived from a limited number of samples aided by prior knowledge. These advances will allow us to reduce scan times dramatically (to less than 10% of conventional scanning) for morphological imaging, support efficient biological imaging for high order diffusion modeling and create hierarchical motion-frozen image volumes of abdominal patients that simultaneously provide breathing, GI contraction, and potentially cardiac motion models with probability density functions that can be used to estimate the impact of intrafraction motion on treatments and eventually select local navigators for real-time monitoring of specific regions that are most sensitive to motion-related impacts on delivered doses to targets or organs at risk. We will investigate this hypothesis by developing a prior knowledge-based compressed sensing method to reconstruct densely sampled DW attenuation curves from sparsely sampled ones; performing principal component analysis of previously scanned FLAIR, contrast-enhanced T1-weighted and Diffusion-Weighted image volumes to support sparse sampling in k-space for anatomic imaging and in b-values for diffusion imaging; investigating potential gains in acceleration of imaging by combining a patient-specific prior with population-derived principal components of structure and diffusion; modeling breathing and peristaltic motion. Finally, we will develop and implement scanning sequences based on the modeled methods for subsampling b-values and anatomy. By these methods, we expect to provide efficient anatomic and high order diffusion imaging, as well as introduce means to automatically extract hierarchical motion models of the patient for use in treatment planning and future support of treatment monitoring. Relevance to PAR 18-484 (for the NCI): This investigation seeks to improve both the efficiency as well as the efficacy of precision radiation therapy for patients with GBMs, other intracranial targets as well as intrahepatic tumors. As Radiation therapy is part of the standard armamentarium of care options for these patients, this research falls within the purview of the NCI.

Public Health Relevance

Magnetic Resonance imaging is rapidly advancing as a primary tool for guiding Radiation Therapy. With routine availability of MR Simulators as well as significant expansion of MR-guided treatment systems, the Radiation Oncology community will benefit greatly from methods to improve the speed and discriminatory power of Magnetic Resonance to monitor the shape, motion, and biological structure of tumors and normal tissues efficiently and accurately. Taking advantage of two concepts, both the lack of significant complexity in descriptions of shape, biology and motion, as well as prior knowledge from both the individual patient as well as populations of similar patients, we will produce highly efficient maps of diffusion for tumor identification and monitoring, patient shape for very rapid scanning both for planning as well as guiding treatments precisely, and finally images that can freeze the patient at selectable combinations of breathing and gastrointestinal motion states, as well as model these motions for more accurate estimation of delivered radiation doses and selection of treatment monitoring methods.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB016079-07
Application #
9979862
Study Section
Radiation Therapeutics and Biology Study Section (RTB)
Program Officer
Liu, Guoying
Project Start
2013-04-01
Project End
2022-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Matakos, Antonis; Balter, James M; Cao, Yue (2017) A Robust Method for Estimating B0 Inhomogeneity Field in the Liver by Mitigating Fat Signals and Phase-Wrapping. Tomography 3:79-88
Liu, Lianli; Jolly, Shruti; Cao, Yue et al. (2017) Female pelvic synthetic CT generation based on joint intensity and shape analysis. Phys Med Biol 62:2935-2949
Bredfeldt, Jeremy S; Liu, Lianli; Feng, Mary et al. (2017) Synthetic CT for MRI-based liver stereotactic body radiotherapy treatment planning. Phys Med Biol 62:2922-2934
Liu, Lianli; Cao, Yue; Fessler, Jeffrey A et al. (2016) A female pelvic bone shape model for air/bone separation in support of synthetic CT generation for radiation therapy. Phys Med Biol 61:169-82
Chapman, Christina Hunter; Prisciandaro, Joann I; Maturen, Katherine E et al. (2016) MRI-Based Evaluation of the Vaginal Cuff in Brachytherapy Planning: Are We Missing the Target? Int J Radiat Oncol Biol Phys 95:743-50
Huang, Ke Colin; Cao, Yue; Baharom, Umar et al. (2016) Phantom-based characterization of distortion on a magnetic resonance imaging simulator for radiation oncology. Phys Med Biol 61:774-90
Price, Ryan G; Kadbi, Mo; Kim, Joshua et al. (2015) Technical Note: Characterization and correction of gradient nonlinearity induced distortion on a 1.0 T open bore MR-SIM. Med Phys 42:5955-60
Hsu, Shu-Hui; Cao, Yue; Lawrence, Theodore S et al. (2015) Quantitative characterizations of ultrashort echo (UTE) images for supporting air-bone separation in the head. Phys Med Biol 60:2869-80
Owrangi, Amir M; Jolly, Shruti; Balter, James M et al. (2015) Clinical implementation of MR-guided vaginal cylinder brachytherapy. J Appl Clin Med Phys 16:490-500

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