Differentiation of tumor recurrence from radiation-induced necrosis (RN) is a critical step in the follow-up management of patients treated with stereotactic radiosurgery for brain tumor. A non-invasive method that is robust in discriminating RN from recurrent tumor using non-invasive method such as MRI is of a significant value for patients and physicians. The hypothesis of this proposed project is that advanced Machine-learning (ML) and image analysis of different MRI imaging information may hold potential for accurately detecting the difference between RN and recurrence of brain tumor is a substantial challenge in the daily practice in Neuro-Oncology. Furthermore, there is a need to study feasibility of translating our ongoing works in brain tumor volume quantitation into potential imaging device. Consequently, this Administrative Supplement propose the following Specific Aims for this study:
Aim 1 : To develop novel methods to discriminate RN from tumor recurrence in MRI.
Aim 2 : To develop and prepare a fast track SBIR proposal (Phase I and II combined) to be submitted soon after this Administrative Supplemental funding expires. If successful, robust discrimination of radiation-induced RN and tumor recurrence will make our current brain tumor and abnormal tissue volume segmentation methods and tools more robust and ready for use in the radiology and oncology practices. Furthermore, the planned SBIR project funding will lead the way to fully explore the possibility of launching a commercial software technology for brain tumor volume quantitation imaging device development.

Public Health Relevance

For ongoing work in our parent RO1 grant we are developing new machine learning and image analysis methods for automatic detection and segmentation of brain tumor in MRI images, which is expected to help patients to have a much better chance of successful treatment. In this Administrative Supplement we will develop methods for discrimination of radiation-induced RN and tumor recurrence that will make our ongoing brain tumor and abnormal tissue volume segmentation methods and tools more robust and ready for use in the radiology and oncology practices. Furthermore, the planned SBIR project funding will lead the way to fully explore the possibility of launching a commercial software technology for brain tumor volume quantitation imaging device development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
3R01EB020683-04S2
Application #
9967445
Study Section
Program Officer
Duan, Qi
Project Start
2019-08-01
Project End
2021-02-28
Budget Start
2019-09-20
Budget End
2021-02-28
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Old Dominion University
Department
Engineering (All Types)
Type
Biomed Engr/Col Engr/Engr Sta
DUNS #
041448465
City
Norfolk
State
VA
Country
United States
Zip Code
23508
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