A key goal of computational neuroscience is to discover how the brain?s structural organization produces its functional behavior, and how impairment of the former causes dysfunction and disease. Rapid advances in neural measurement technologies are finally beginning to enable in vivo measurements of large-scale functional organization (via EEG, MEG, fMRI, PET, optical imaging) and the underlying structural connectivity architecture (via diffusion MRI, tractography). Traditional non-linear numerical simulations of single neurons or local circuits is challenging to extrapolate to macroscopic brain dynamics, and deterministic brain network models are needed that can integrate across modalities and scales. We propose an ambitious multi-scale, parsimonious and analytic model of brain function based on spectral graph theory. Bayesian inference using graphical modeling is proposed to deduce structure from function. These algorithms will be implemented and shared via a Network Dynamics Workbench that can be used by neuroscientists and clinicians to perturb structure and generate hypotheses regarding functional impairment in stimulus and disease conditions. The key insight underlying this proposal is that the emergent macroscopic behavior of the brain is essentially deterministic, and is undergirded by network ?eigen-modes?. We will develop graph models of neural dynamics that are accessible analytically by simple equations rather than via numerical simulations. These models will be minimal and simple, and linear wherever appropriate. The final deliverable is a Network Dynamics Workbench for experimentally interrogating brain function and dysfunction. Relevance Neurological and psychiatric disorders constitute an overwhelming burden of disease today, especially in a rapidly aging population. A validated model of brain function predicted from structure will provide a critical tool in understanding and fighting these disorders.

Public Health Relevance

A key goal of computational neuroscience is to discover how the brain?s structural organization produces its functional behavior, and how structural impairment causes dysfunction. We propose an ambitious multi-scale, parsimonious and analytic graph theoretic model of brain function, and a Bayesian inference algorithm to achieve multi-modality fusion. We envisage a computational workbench that can interrogate how pathology or external stimulus perturbs the dynamics of the brain and causes dysfunction.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
1R01EB022717-01
Application #
9170597
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Peng, Grace
Project Start
2016-09-30
Project End
2019-06-30
Budget Start
2016-09-30
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
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