Edited magnetic resonance spectroscopy allows the non-invasive detection of low-concentration metabolites within the brain, such as the inhibitory neurotransmitter GABA and the redox compound glutathione (GSH). The signals of such metabolites are often overlapped in the MR spectrum, but a tailored spectral editing experiment can selectively retrieve signals of interest. Such ?edited? approaches generally focus on measuring a single metabolite (i.e. either GABA or GSH) in a single brain region; the main goal of this proposal is to develop Hadamard-edited experiments that detect GABA and GSH simultaneously, in a single acquisition. We will develop the Hadamard-encoded HERMES approach, and multi-voxel Hadamard editing, using the SHERPA and HERMES-SHERPA approaches. The resulting data acquisition, post- processing and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.
Magnetic resonance spectroscopy measures the concentration of naturally occurring chemicals within the body using an MRI scanner to, often focusing on one particular chemical and location using ?edited? methods. This project will develop new experimental and data processing tools to allow simultaneous edited measurements of two key brain compoudnds, GABA and glutathione.
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| Oeltzschner, Georg; Chan, Kimberly L; Saleh, Muhammad G et al. (2018) Hadamard editing of glutathione and macromolecule-suppressed GABA. NMR Biomed 31: |
| Gong, Tao; Xiang, Yuanyuan; Saleh, Muhammad G et al. (2018) Inhibitory motor dysfunction in parkinson's disease subtypes. J Magn Reson Imaging 47:1610-1615 |
| Mikkelsen, Mark; Saleh, Muhammad G; Near, Jamie et al. (2018) Frequency and phase correction for multiplexed edited MRS of GABA and glutathione. Magn Reson Med 80:21-28 |
| Oeltzschner, Georg; Snoussi, Karim; Puts, Nicolaas A et al. (2018) Effects of eddy currents on selective spectral editing experiments at 3T. J Magn Reson Imaging 47:673-681 |
| Saleh, Muhammad G; Mikkelsen, Mark; Oeltzschner, Georg et al. (2018) Simultaneous editing of GABA and glutathione at 7T using semi-LASER localization. Magn Reson Med 80:474-479 |
| Mikkelsen, Mark; Barker, Peter B; Bhattacharyya, Pallab K et al. (2017) Big GABA: Edited MR spectroscopy at 24 research sites. Neuroimage 159:32-45 |
