Abstract

The objectives of the proposed research are to investigate the GSH-dependent substitution vs. reduction of benzyl halides, to study the dehydrohalogenation of polyhalogenated alkanes, to study the microsomal reduction of polyhalogenated alkanes, to study the GSH-dependent dehalogenation of vic-dihalides, to study the mechanisms by which 1,2-dichloroethane and 1,2-dibromoethane produce hepatic and renal toxicity, to study the enzymes involved in the reductive dehalogenation of alpha-haloketones and to study enzyme catalyzed nucleophilic substitution reactions of halogenated olefins and to determine the relationship of this reaction to the production of nephrotoxicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003127-04
Application #
3250268
Study Section
Toxicology Study Section (TOX)
Project Start
1982-07-01
Project End
1986-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Rochester
Department
Type
Schools of Medicine
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Board, Philip G; Anders, M W (2007) Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones. Chem Res Toxicol 20:149-54
Blackburn, Anneke C; Matthaei, Klaus I; Lim, Cindy et al. (2006) Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol 69:650-7
Anders, M W (2005) Formation and toxicity of anesthetic degradation products. Annu Rev Pharmacol Toxicol 45:147-76
Lim, Cindy E L; Matthaei, Klaus I; Blackburn, Anneke C et al. (2004) Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol 165:679-93
Lantum, Hoffman B M; Iyer, Ramaswamy A; Anders, M W (2004) Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities. Biochem Pharmacol 67:1421-6
Anderson, Wayne B; Board, Philip G; Anders, M W (2004) Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles. Chem Res Toxicol 17:650-62
Lantum, Hoffman B M; Cornejo, Judith; Pierce, Robert H et al. (2003) Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency. Toxicol Sci 74:192-202
Jolivette, Larry J; Anders, M W (2003) Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes. Chem Res Toxicol 16:137-44
Board, Philip G; Taylor, Matthew C; Coggan, Marjorie et al. (2003) Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem J 374:731-7
Lantum, Hoffman B M; Baggs, Raymond B; Krenitsky, Daria M et al. (2002) Nephrotoxicity of chlorofluoroacetic acid in rats. Toxicol Sci 70:261-8

Showing the most recent 10 out of 113 publications