Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004071-02
Application #
3251941
Study Section
Toxicology Study Section (TOX)
Project Start
1987-08-01
Project End
1990-07-31
Budget Start
1988-08-01
Budget End
1989-07-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Mattia, C J; Ali, S F; Bondy, S C (1993) Toluene-induced oxidative stress in several brain regions and other organs. Mol Chem Neuropathol 18:313-28
Mattia, C J; Adams Jr, J D; Bondy, S C (1993) Free radical induction in the brain and liver by products of toluene catabolism. Biochem Pharmacol 46:103-10
Zawia, N H; Bondy, S C (1992) Transcription-dependent and -independent induction of cerebral ornithine decarboxylase. J Neurochem 58:736-9
LeBel, C P; Ali, S F; Bondy, S C (1992) Deferoxamine inhibits methyl mercury-induced increases in reactive oxygen species formation in rat brain. Toxicol Appl Pharmacol 112:161-5
Ali, S F; LeBel, C P; Bondy, S C (1992) Reactive oxygen species formation as a biomarker of methylmercury and trimethyltin neurotoxicity. Neurotoxicology 13:637-48
Mattia, C J; LeBel, C P; Bondy, S C (1991) Effects of toluene and its metabolites on cerebral reactive oxygen species generation. Biochem Pharmacol 42:879-82
Vendrell, M; Zawia, N H; Serratosa, J et al. (1991) c-fos and ornithine decarboxylase gene expression in brain as early markers of neurotoxicity. Brain Res 544:291-6
Bondy, S C; McKee, M (1991) Disruption of the potential across the synaptosomal plasma membrane and mitochondria by neurotoxic agents. Toxicol Lett 58:13-21
LeBel, C P; Bondy, S C (1991) Persistent protein damage despite reduced oxygen radical formation in the aging rat brain. Int J Dev Neurosci 9:139-46
Bondy, S C; McKee, M; Le Bel, C P (1990) Changes in synaptosomal pH and rates of oxygen radical formation induced by chlordecone. Mol Chem Neuropathol 13:95-106

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