Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004112-09
Application #
2153570
Study Section
Safety and Occupational Health Study Section (SOH)
Project Start
1986-07-01
Project End
1997-06-30
Budget Start
1995-04-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Type
Schools of Pharmacy
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
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Ross, D; Siegel, D; Schattenberg, D G et al. (1996) Cell-specific activation and detoxification of benzene metabolites in mouse and human bone marrow: identification of target cells and a potential role for modulation of apoptosis in benzene toxicity. Environ Health Perspect 104 Suppl 6:1177-82
Ross, D (1996) Metabolic basis of benzene toxicity. Eur J Haematol Suppl 60:111-8
Miller, A C; Schattenberg, D G; Malkinson, A M et al. (1994) Decreased content of the IL1 alpha processing enzyme calpain in murine bone marrow-derived macrophages after treatment with the benzene metabolite hydroquinone. Toxicol Lett 74:177-84
Levay, G; Ross, D; Bodell, W J (1993) Peroxidase activation of hydroquinone results in the formation of DNA adducts in HL-60 cells, mouse bone marrow macrophages and human bone marrow. Carcinogenesis 14:2329-34
Goon, D; Saxena, M; Awasthi, Y C et al. (1993) Activity of mouse liver glutathione S-transferases toward trans,trans-muconaldehyde and trans-4-hydroxy-2-nonenal. Toxicol Appl Pharmacol 119:175-80
Goon, D; Matsuura, J; Ross, D (1993) Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential markers of benzene ring cleavage reactions. Chem Biol Interact 88:37-53
Ganousis, L G; Goon, D; Zyglewska, T et al. (1992) Cell-specific metabolism in mouse bone marrow stroma: studies of activation and detoxification of benzene metabolites. Mol Pharmacol 42:1118-25
Monks, T J; Hanzlik, R P; Cohen, G M et al. (1992) Quinone chemistry and toxicity. Toxicol Appl Pharmacol 112:2-16
Goon, D; Cheng, X; Ruth, J A et al. (1992) Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite. Toxicol Appl Pharmacol 114:147-55

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