Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004312-08
Application #
2153637
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1987-03-01
Project End
1997-02-28
Budget Start
1994-03-01
Budget End
1997-02-28
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Veterinary Sciences
Type
Schools of Earth Sciences/Natur
DUNS #
City
Storrs-Mansfield
State
CT
Country
United States
Zip Code
06269
Moephuli, S R; Klein, N W; Baldwin, M T et al. (1997) Effects of methionine on the cytoplasmic distribution of actin and tubulin during neural tube closure in rat embryos. Proc Natl Acad Sci U S A 94:543-8
Chambers, B J; Klein, N W; Nosel, P G et al. (1995) Methionine overcomes neural tube defects in rat embryos cultured on sera from laminin-immunized monkeys. J Nutr 125:1587-99
Nadler, D M; Klein, N W; Aramli, L A et al. (1995) The direct embryotoxicity of immunoglobulin G fractions from patients with systemic lupus erythematosus. Am J Reprod Immunol 34:349-55
Chambers, B J; Klein, N W; Conrad, S H et al. (1995) Reproduction and sera embryotoxicity after immunization of monkeys with the laminin peptides YIGSR, RGD, and IKVAV. Proc Natl Acad Sci U S A 92:6818-22
Ferrari, D A; Gilles, P A; Klein, N W et al. (1994) Rat embryo development on human sera is related to numbers of previous spontaneous abortions and nutritional factors. Am J Obstet Gynecol 170:228-36
Izumi, H; Garfield, R E; Makino, Y et al. (1994) Gestational changes in endothelium-dependent vasorelaxation in human umbilical artery. Am J Obstet Gynecol 170:236-45
Nosel, P G; Klein, N W (1992) Methionine decreases the embryotoxicity of sodium valproate in the rat: in vivo and in vitro observations. Teratology 46:499-507
Robbins, B; Klein, N W; Cavalcanti, H (1991) Toxicity of sera from individuals with Chagas' disease to cultured rat embryos: role of antibodies to laminin. Teratology 44:561-70
Coelho, C N; Klein, N W (1990) Methionine and neural tube closure in cultured rat embryos: morphological and biochemical analyses. Teratology 42:437-51
Weeks, B S; Gamache, P; Klein, N W et al. (1990) Acetaminophen toxicity to cultured rat embryos. Teratog Carcinog Mutagen 10:361-71

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