Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004325-09
Application #
2153648
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1987-05-01
Project End
1997-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Gardner, Olivia S; Dewar, Brian J; Earp, H Shelton et al. (2003) Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. J Biol Chem 278:46261-9
Rose, M L; Bradford, B U; Germolec, D R et al. (2001) Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha. Toxicol Appl Pharmacol 170:39-45
Rusyn, I; Kadiiska, M B; Dikalova, A et al. (2001) Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Mol Pharmacol 59:744-50
Rusyn, I; Yamashina, S; Segal, B H et al. (2000) Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Res 60:4798-803
Rose, M L; Rusyn, I; Bojes, H K et al. (2000) Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation. Mutat Res 448:179-92
Rusyn, I; Rose, M L; Bojes, H K et al. (2000) Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. Antioxid Redox Signal 2:607-21
Rusyn, I; Bradham, C A; Cohn, L et al. (1999) Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis 20:2095-100
Rose, M L; Cattley, R C; Dunn, C et al. (1999) Dietary glycine prevents the development of liver tumors caused by the peroxisome proliferator WY-14,643. Carcinogenesis 20:2075-81
Rose, M L; Rivera, C A; Bradford, B U et al. (1999) Kupffer cell oxidant production is central to the mechanism of peroxisome proliferators. Carcinogenesis 20:27-33
Rose, M L; Madren, J; Bunzendahl, H et al. (1999) Dietary glycine inhibits the growth of B16 melanoma tumors in mice. Carcinogenesis 20:793-8

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