Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004640-02S1
Application #
3252747
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1991-06-01
Project End
1995-05-31
Budget Start
1992-07-01
Budget End
1993-05-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Kentucky
Department
Type
Schools of Medicine
DUNS #
832127323
City
Lexington
State
KY
Country
United States
Zip Code
40506
Hong, C B; Fredenburg, A M; Dickey, K M et al. (2000) Glomerular lesions in male rabbits treated with aluminium lactate: with special reference to microaneurysm formation. Exp Toxicol Pathol 52:139-43
Yokel, R A; O'Callaghan, J P (1998) An aluminum-induced increase in GFAP is attenuated by some chelators. Neurotoxicol Teratol 20:55-60
Yokel, R A; Meurer, K A; Hong, C B et al. (1997) Short-term oral 3-hydroxypyridin-4-one dosing increases aluminum excretion and partially reverses aluminum-induced toxicity in the rabbit independent of chelator lipophilicity. Drug Metab Dispos 25:182-90
Yokel, R A (1996) Aluminum chelation by 3-hydroxypyridin-4-ones in the rat demonstrated by microdialysis. Biol Trace Elem Res 53:193-203
Xie, C X; Mattson, M P; Lovell, M A et al. (1996) Intraneuronal aluminum potentiates iron-induced oxidative stress in cultured rat hippocampal neurons. Brain Res 743:271-7
Skinner, T L; Meurer, K A; Yokel, R A (1996) HPLC quantitation of a very hydrophilic 3-hydroxypyridin-4-one chelator using a simple separation procedure and the baseline file subtraction method. J Chromatogr Sci 34:52-7
Xie, C X; Yokel, R A (1996) Aluminum facilitation of iron-mediated lipid peroxidation is dependent on substrate, pH and aluminum and iron concentrations. Arch Biochem Biophys 327:222-6
Yokel, R A; Meurer, K A; Skinner, T L et al. (1996) The 3-hydroxypyridin-4-ones more effectively chelate aluminum in a rabbit model of aluminum intoxication than does desferrioxamine. Drug Metab Dispos 24:105-11
Allen, D D; Orvig, C; Yokel, R A (1995) Evidence for energy-dependent transport of aluminum out of brain extracellular fluid. Toxicology 98:31-9
Xie, C X; St Pyrek, J; Porter, W H et al. (1995) Hydroxyl radical generation in rat brain is initiated by iron but not aluminum, as determined by microdialysis with salicylate trapping and GC-MS analysis. Neurotoxicology 16:489-96

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