Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004648-04A1S1
Application #
3252765
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1992-08-01
Project End
1995-03-31
Budget Start
1992-08-01
Budget End
1993-03-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Washington State University
Department
Type
Schools of Pharmacy
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Kato-Weinstein, J; Stauber, A J; Orner, G A et al. (2001) Differential effects of dihalogenated and trihalogenated acetates in the liver of B6C3F1 mice. J Appl Toxicol 21:81-9
Kato-Weinstein, J; Lingohr, M K; Orner, G A et al. (1998) Effects of dichloroacetate on glycogen metabolism in B6C3F1 mice. Toxicology 130:141-54
Austin, E W; Bull, R J (1997) Effect of pretreatment with dichloroacetate or trichloroacetate on the metabolism of bromodichloroacetate. J Toxicol Environ Health 52:367-83
Stauber, A J; Bull, R J (1997) Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA). Toxicol Appl Pharmacol 144:235-46
Parrish, J M; Austin, E W; Stevens, D K et al. (1996) Haloacetate-induced oxidative damage to DNA in the liver of male B6C3F1 mice. Toxicology 110:103-11
Austin, E W; Parrish, J M; Kinder, D H et al. (1996) Lipid peroxidation and formation of 8-hydroxydeoxyguanosine from acute doses of halogenated acetic acids. Fundam Appl Toxicol 31:77-82
Austin, E W; Okita, J R; Okita, R T et al. (1995) Modification of lipoperoxidative effects of dichloroacetate and trichloroacetate is associated with peroxisome proliferation. Toxicology 97:59-69
Bruschi, S A; Bull, R J (1993) In vitro cytotoxicity of mono-, di-, and trichloroacetate and its modulation by hepatic peroxisome proliferation. Fundam Appl Toxicol 21:366-75
Larson, J L; Bull, R J (1992) Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol Appl Pharmacol 115:268-77
Nelson, M A; Sanchez, I M; Bull, R J et al. (1990) Increased expression of c-myc and c-Ha-ras in dichloroacetate and trichloroacetate-induced liver tumors in B6C3F1 mice. Toxicology 64:47-57

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