Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES004659-04
Application #
3252787
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1990-08-01
Project End
1992-06-30
Budget Start
1990-12-15
Budget End
1992-06-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Mersch-Sundermann, V; Klopman, G; Rosenkranz, H S (1996) Chemical structure and genotoxicity: studies of the SOS chromotest. Mutat Res 340:81-91
De Flora, S; Rosenkranz, H S; Klopman, G (1994) Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium. Mutagenesis 9:39-45
Sakai, T; Klopman, G; Rosenkranz, H S (1994) Structural basis for the induction of preneoplastic glutathione S-transferase positive foci by hepatocarcinogens. Teratog Carcinog Mutagen 14:219-37
McGregor, D B; Pangrekar, J; Rosenkranz, H S et al. (1994) A reexamination of the low prevalence of carcinogens in an early carcinogen screen. Regul Toxicol Pharmacol 19:97-105
Zhang, Y P; Van Praagh, A; Klopman, G et al. (1994) Structural basis of the induction of unscheduled DNA synthesis in rat hepatocytes. Mutagenesis 9:141-9
Mersch-Sundermann, V; Rosenkranz, H S; Klopman, G (1994) The structural basis of the genotoxicity of nitroarenofurans and related compounds. Mutat Res 304:271-84
Rosenkranz, H S; Klopman, G (1994) Structural implications of the ICPEMC method for quantifying genotoxicity data. Mutat Res 305:99-116
Mersch-Sundermann, V; Schneider, U; Klopman, G et al. (1994) SOS induction in Escherichia coli and Salmonella mutagenicity: a comparison using 330 compounds. Mutagenesis 9:205-24
Takihi, N; Zhang, Y P; Klopman, G et al. (1993) An approach for evaluating and increasing the informational content of mutagenicity and clastogenicity data bases. Mutagenesis 8:257-64
Rosenkranz, H S; Klopman, G (1993) Structural relationships between mutagenicity, maximum tolerated dose, and carcinogenicity in rodents. Environ Mol Mutagen 21:193-206

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