Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES004802-02
Application #
3252921
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1989-02-01
Project End
1990-04-30
Budget Start
1990-02-01
Budget End
1990-04-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Public Health
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Sakamoto, T; Repasky, W T; Uchida, K et al. (1996) Modulation of cell death pathways to apoptosis and necrosis of H2O2-treated rat thymocytes by lipocortin I. Biochem Biophys Res Commun 220:643-7
Uchida, Y; Jun, T; Ninomiya, H et al. (1996) Involvement of endothelins in immediate and late asthmatic responses of guinea pigs. J Pharmacol Exp Ther 277:1622-9
Sakamoto, T; Repasky, W T; Chen, J et al. (1995) Down-regulation of bcl-xs gene expression in rat thymocytes by dexamethasone. Biochem Biophys Res Commun 215:511-6
Hirata, F; Lee, J Y; Sakamoto, T et al. (1994) IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. Biochem Biophys Res Commun 203:1889-96
Lee, J Y; Uchida, Y; Sakamoto, T et al. (1994) Alteration of G protein levels in antigen-challenged guinea pigs. J Pharmacol Exp Ther 271:1713-20
Wills-Karp, M; Uchida, Y; Lee, J Y et al. (1993) Organ culture with proinflammatory cytokines reproduces impairment of the beta-adrenoceptor-mediated relaxation in tracheas of a guinea pig antigen model. Am J Respir Cell Mol Biol 8:153-9
Endo, T; Uchida, Y; Matsumoto, H et al. (1992) Regulation of endothelin-1 synthesis in cultured guinea pig airway epithelial cells by various cytokines. Biochem Biophys Res Commun 186:1594-9
Uchida, Y; Hamada, M; Kameyama, M et al. (1992) ET-1 induced bronchoconstriction in the early phase but not late phase of anesthetized dogs is inhibited by indomethacin and ICI 198615. Biochem Biophys Res Commun 183:1197-202
Ninomiya, H; Uchida, Y; Saotome, M et al. (1992) Endothelins constrict guinea pig tracheas by multiple mechanisms. J Pharmacol Exp Ther 262:570-6
Uchida, Y; Ninomiya, H; Sakamoto, T et al. (1992) ET-1 released histamine from guinea pig pulmonary but not peritoneal mast cells. Biochem Biophys Res Commun 189:1196-201

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