Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES005452-06
Application #
2154109
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1991-06-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Washington State University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164

  Publications

Zhang, J G; Tirmenstein, M A; Nicholls-Grzemski, F A et al. (2001) Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. Arch Biochem Biophys 393:87-96
Tirmenstein, M A; Nicholls-Grzemski, F A; Schmittgen, T D et al. (2000) Glutathione-dependent regulation of nitric oxide production in isolated rat hepatocyte suspensions. Antioxid Redox Signal 2:767-77
Tirmenstein, M A; Nicholls-Grzemski, F A; Zhang, J G et al. (2000) Glutathione depletion and the production of reactive oxygen species in isolated hepatocyte suspensions. Chem Biol Interact 127:201-17
Tirmenstein, M A; Nicholls-Grzemski, F A; Schmittgen, T D et al. (2000) Characterization of nitric oxide production following isolation of rat hepatocytes. Toxicol Sci 53:56-62
Nicholls-Grzemski, F A; Tirmenstein, M A; Fariss, M W (1999) Time-dependent production of nitric oxide by rat hepatocyte suspensions. Biochem Pharmacol 57:1223-6
Tirmenstein, M A; Ge, X; Elkins, C R et al. (1999) Administration of the tris salt of alpha-tocopheryl hemisuccinate inactivates CYP2E1, enhances microsomal alpha-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity. Free Radic Biol Med 26:825-35
Tirmenstein, M A; Watson, B W; Haar, N C et al. (1998) Sensitive method for measuring tissue alpha-tocopherol and alpha-tocopheryloxybutyric acid by high-performance liquid chromatography with fluorometric detection. J Chromatogr B Biomed Sci Appl 707:308-11
Tirmenstein, M A; Pierce, C A; Leraas, T L et al. (1998) A fluorescence plate reader assay for monitoring the susceptibility of biological samples to lipid peroxidation. Anal Biochem 265:246-52
Fariss, M W; Lippman, H R; Mumaw, V R et al. (1997) Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. Toxicol Lett 90:133-44
Tirmenstein, M A; Leraas, T L; Fariss, M W (1997) alpha-Tocopheryl hemisuccinate administration increases rat liver subcellular alpha-tocopherol levels and protects against carbon tetrachloride-induced hepatotoxicity. Toxicol Lett 92:67-77

Showing the most recent 10 out of 17 publications