The objective of this research is to develop and experimentally validate algorithms which predict the absorbed dose following dermal exposure to chemically contaminated soils using known, or easily determined parameters such as exposure time, octanol-water partitioning, molecular weight, soil particle size distribution, and soil organic and water content. The basic assumption is that systemic human health risk from chemical exposure is dependent upon the mass of chemical which is absorbed. Since the skin is a major barrier to many chemicals, the absorbed dose may be significantly less than the exposed dose. Additionally, the large number of potential soil contaminants coupled with a wide variety of potential exposure scenarios, makes the experimental testing of every possible case impossible. In contrast, the use of a validated predictive algorithm would be useful to estimate dermal absorption following exposure to contaminated soils. Thus, this research proposes to systematically evaluate dermal absorption from soils by combining mathematical models with in vitro and in vivo experiments to produce predictive algorithms for the absorbed dose.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006825-02
Application #
2155731
Study Section
Special Emphasis Panel (ZRG7-SSS-9 (08))
Project Start
1994-07-15
Project End
1998-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Colorado School of Mines
Department
Physics
Type
Other Domestic Higher Education
DUNS #
City
Golden
State
CO
Country
United States
Zip Code
80401
Choate, LaDonna M; Ranville, James F; Bunge, Annette L et al. (2006) Dermally adhered soil: 1. Amount and particle-size distribution. Integr Environ Assess Manag 2:375-84
Choate, LaDonna M; Ranville, James F; Bunge, Annette L et al. (2006) Dermally adhered soil: 2. Reconstruction of dry-sieve particle-size distributions from wet-sieve data. Integr Environ Assess Manag 2:385-90
Touraille, G D; McCarley, K D; Bunge, A L et al. (2005) Percutaneous absorption of 4-cyanophenol from freshly contaminated soil in vitro: effects of soil loading and contamination concentration. Environ Sci Technol 39:3723-31
McCarley, Kelly D; Bunge, Annette L (2003) Absorption into silicone rubber membranes from powders and aqueous solutions. Int J Pharm 250:169-80
McCarley, K D; Bunge, A L (2001) Pharmacokinetic models of dermal absorption. J Pharm Sci 90:1699-719
McCarley, K D; Bunge, A L (2000) Physiologically relevant two-compartment pharmacokinetic models for skin. J Pharm Sci 89:1212-35
Reddy, M B; McCarley, K D; Bunge, A L (1998) Physiologically relevant one-compartment pharmacokinetic models for skin. 2. Comparison of models when combined with a systemic pharmacokinetic model. J Pharm Sci 87:482-90
McCarley, K D; Bunge, A L (1998) Physiologically relevant one-compartment pharmacokinetic models for skin. 1. Development of models. J Pharm Sci 87:470-81
Parks, J M; Cleek, R L; Bunge, A L (1997) Chemical release from topical formulations across synthetic membranes: infinite dose. J Pharm Sci 86:187-92