Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006882-02
Application #
2155816
Study Section
Radiation Study Section (RAD)
Project Start
1995-04-01
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Dermatology
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Abdel-Malek, Z A; Scott, M C; Furumura, M et al. (2001) The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. J Cell Sci 114:1019-24
Abdel-Malek, Z; Scott, M C; Suzuki, I et al. (2000) The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation. Pigment Cell Res 13 Suppl 8:156-62
Suzuki, I; Im, S; Tada, A et al. (1999) Participation of the melanocortin-1 receptor in the UV control of pigmentation. J Investig Dermatol Symp Proc 4:29-34
Im, S; Moro, O; Peng, F et al. (1998) Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. Cancer Res 58:47-54
Can, G; Abdel-Malek, Z; Porter-Gill, P A et al. (1998) Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture. J Invest Dermatol 111:485-91
Tada, A; Suzuki, I; Im, S et al. (1998) Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell Growth Differ 9:575-84
Scott, G; Cassidy, L; Abdel-Malek, Z (1997) Alpha-melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation. Exp Cell Res 237:19-28
Suzuki, I; Tada, A; Ollmann, M M et al. (1997) Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin. J Invest Dermatol 108:838-42
Suzuki, I; Cone, R D; Im, S et al. (1996) Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology 137:1627-33
Medrano, E E; Im, S; Yang, F et al. (1995) Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein. Cancer Res 55:4047-52

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