Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES007781-01A1
Application #
2157242
Study Section
Special Emphasis Panel (ZRG3-BNP (02))
Project Start
1996-09-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Dooley, Patricia A; Zhang, Mingzhou; Korbel, Gregory A et al. (2003) NMR determination of the conformation of a trimethylene interstrand cross-link in an oligodeoxynucleotide duplex containing a 5'-d(GpC) motif. J Am Chem Soc 125:62-72
Kowalczyk, Agnieszka; Carmical, J Russ; Zou, Yue et al. (2002) Intrastrand DNA cross-links as tools for studying DNA replication and repair: two-, three-, and four-carbon tethers between the N(2) positions of adjacent guanines. Biochemistry 41:3109-18
Nechev, L V; Zhang, M; Tsarouhtsis, D et al. (2001) Synthesis and characterization of nucleosides and oligonucleotides bearing adducts of butadiene epoxides on adenine n(6) and guanine n(2). Chem Res Toxicol 14:379-88
Nechev, L V; Kozekov, I; Harris, C M et al. (2001) Stereospecific synthesis of oligonucleotides containing crotonaldehyde adducts of deoxyguanosine. Chem Res Toxicol 14:1506-12
Kowalczyk, A; Harris, C M; Harris, T M (2001) Synthesis and characterization of oligodeoxynucleotides containing an N1 beta-hydroxyalkyl adduct of 2'-deoxyinosine. Chem Res Toxicol 14:746-53
Kozekov, I D; Nechev, L V; Sanchez, A et al. (2001) Interchain cross-linking of DNA mediated by the principal adduct of acrolein. Chem Res Toxicol 14:1482-5
Dooley, P A; Tsarouhtsis, D; Korbel, G A et al. (2001) Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5'-(CpG) motif: model of a malondialdehyde cross-link. J Am Chem Soc 123:1730-9
VanderVeen, L A; Hashim, M F; Nechev, L V et al. (2001) Evaluation of the mutagenic potential of the principal DNA adduct of acrolein. J Biol Chem 276:9066-70
Rodriguez, D A; Kowalczyk, A; Ward Jr, J B et al. (2001) Point mutations induced by 1,2-epoxy-3-butene N1 deoxyinosine adducts. Environ Mol Mutagen 38:292-6
Nechev, L V; Harris, C M; Harris, T M (2000) Synthesis of nucleosides and oligonucleotides containing adducts of acrolein and vinyl chloride. Chem Res Toxicol 13:421-9

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