Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
1R01ES007847-01A1
Application #
2157332
Study Section
Special Emphasis Panel (ZRG4-ALTX-2)
Project Start
1996-08-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Adirondack Biomedical Research Institute
Department
Type
DUNS #
City
Lake Placid
State
NY
Country
United States
Zip Code
12946
Stevens, J L; Liu, H; Halleck, M et al. (2000) Linking gene expression to mechanisms of toxicity. Toxicol Lett 112-113:479-86
van de Water, B; Tijdens, I B; Verbrugge, A et al. (2000) Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells. J Biol Chem 275:25805-13
Zhan, Y; van de Water, B; Wang, Y et al. (1999) The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells. Oncogene 18:6505-12
van de Water, B; Nagelkerke, J F; Stevens, J L (1999) Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cells. J Biol Chem 274:13328-37
Liu, H; Miller, E; van de Water, B et al. (1998) Endoplasmic reticulum stress proteins block oxidant-induced Ca2+ increases and cell death. J Biol Chem 273:12858-62
Kruidering, M; van de Water, B; Zhan, Y et al. (1998) Cisplatin effects on F-actin and matrix proteins precede renal tubular cell detachment and apoptosis in vitro. Cell Death Differ 5:601-14
Zhan, Y; Cleveland, J L; Stevens, J L (1997) A role for c-myc in chemically induced renal-cell death. Mol Cell Biol 17:6755-64