Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES008389-03
Application #
2856868
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1997-01-01
Project End
1999-04-30
Budget Start
1999-01-01
Budget End
1999-04-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Arakawa, Hirohumi; Wu, Feng; Costa, Max et al. (2006) Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites. Carcinogenesis 27:639-45
Feng, Zhaohui; Hu, Wenwei; Tang, Moon-Shong (2004) Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis. Proc Natl Acad Sci U S A 101:8598-602
Feng, Zhaohui; Hu, Wenwei; Rom, William N et al. (2003) Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells. Carcinogenesis 24:771-8
Feng, Zhaohui; Hu, Wenwei; Amin, Shantu et al. (2003) Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells. Biochemistry 42:7848-54
Feng, Zhaohui; Hu, Wenwei; Chasin, Lawrence A et al. (2003) Effects of genomic context and chromatin structure on transcription-coupled and global genomic repair in mammalian cells. Nucleic Acids Res 31:5897-906
Feng, Zhaohui; Hu, Wenwei; Chen, James X et al. (2002) Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer. J Natl Cancer Inst 94:1527-36
Hu, Wenwei; Feng, Zhaohui; Eveleigh, Jamie et al. (2002) The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma. Carcinogenesis 23:1781-9
Feng, Zhaohui; Hu, Wenwei; Rom, William N et al. (2002) N-hydroxy-4-aminobiphenyl-DNA binding in human p53 gene: sequence preference and the effect of C5 cytosine methylation. Biochemistry 41:6414-21
Hu, Wenwei; Feng, Zhaohui; Chasin, Lawrence A et al. (2002) Transcription-coupled and transcription-independent repair of cyclobutane pyrimidine dimers in the dihydrofolate reductase gene. J Biol Chem 277:38305-10
Feng, Zhaohui; Hu, Wenwei; Komissarova, Elena et al. (2002) Transcription-coupled DNA repair is genomic context-dependent. J Biol Chem 277:12777-83

Showing the most recent 10 out of 24 publications