Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES010233-03
Application #
6382341
Study Section
Special Emphasis Panel (ZES1-SRC (99))
Program Officer
Mcclure, Michael
Project Start
1999-07-01
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
3
Fiscal Year
2001
Total Cost
$290,044
Indirect Cost
Name
Population Council
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10017
Hu, Guo-Xin; Lian, Qing-Quan; Ge, Ren-Shan et al. (2009) Phthalate-induced testicular dysgenesis syndrome: Leydig cell influence. Trends Endocrinol Metab 20:139-45
Lin, Han; Lian, Qing-Quan; Hu, Guo-Xin et al. (2009) In utero and lactational exposures to diethylhexyl-phthalate affect two populations of Leydig cells in male Long-Evans rats. Biol Reprod 80:882-8
Ge, Renshan; Chen, Guorong; Hardy, Matthew P (2008) The role of the Leydig cell in spermatogenic function. Adv Exp Med Biol 636:255-69
Lin, Han; Ge, Ren-Shan; Chen, Guo-Rong et al. (2008) Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc Natl Acad Sci U S A 105:7218-22
Ge, Ren-Shan; Chen, Guo-Rong; Tanrikut, Cigdem et al. (2007) Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations. Reprod Toxicol 23:366-73
Ge, Ren-Shan; Chen, Guo-Rong; Dong, Qiang et al. (2007) Biphasic effects of postnatal exposure to diethylhexylphthalate on the timing of puberty in male rats. J Androl 28:513-20
Akingbemi, Benson T (2005) Estrogen regulation of testicular function. Reprod Biol Endocrinol 3:51
Akingbemi, Benson T; Ge, Renshan; Klinefelter, Gary R et al. (2004) Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc Natl Acad Sci U S A 101:775-80
Akingbemi, Benson T; Sottas, Chantal M; Koulova, Anna I et al. (2004) Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary luteinizing hormone secretion and decreased steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 145:592-603
Akingbemi, Benson T; Ge, Renshan; Rosenfeld, Cheryl S et al. (2003) Estrogen receptor-alpha gene deficiency enhances androgen biosynthesis in the mouse Leydig cell. Endocrinology 144:84-93

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