This is a continuation of a long-term endeavor to understand the visual cortex of cats and monkeys in terms of its single-cell physiology, and the groupings of cells according to their physiological properties. We wish to learn more, in both area 17 and 18, about the relationships between the different groupings, particularly between orientation columns, ocular dominance columns, and the recently discovered cytochrome blobs. The blobs are distinguished from the background by a number of enzymatic stains, by 2-deoxyglucose, and by proline injection into the eye or the lateral geniculate body. We plan to study the single-cell physiology of these structures, comparing receptive fields of cells within and outside the blobs. We will examine their inputs, outputs, and intrinsic connections, using a variety of anatomical methods: the Nauta method, retrograde transport of horseradish peroxidase, orthograde transport of aminoacide, and the Golgi technique. We will study their enzyme histochemistry, development, and differences in different species including normal and blind or amblyopic humans.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000605-40
Application #
6125165
Study Section
Special Emphasis Panel (ZRG1-VISB (04))
Program Officer
Oberdorfer, Michael
Project Start
1977-12-01
Project End
2003-11-30
Budget Start
1999-12-01
Budget End
2000-11-30
Support Year
40
Fiscal Year
2000
Total Cost
$560,919
Indirect Cost
Name
Harvard University
Department
Neurology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Hubel, David H; Howe, Piers D L; Duffy, Amanda M et al. (2009) Scotopic foveal afterimages. Perception 38:313-6
Conway, Bevil R; Hubel, David H; Livingstone, Margaret S (2002) Color contrast in macaque V1. Cereb Cortex 12:915-25
Livingstone, M S; Nori, S; Freeman, D C et al. (1995) Stereopsis and binocularity in the squirrel monkey. Vision Res 35:345-54
Hubel, D H; Livingstone, M S (1990) Color and contrast sensitivity in the lateral geniculate body and primary visual cortex of the macaque monkey. J Neurosci 10:2223-37
Livingstone, M S; Hubel, D H (1988) Do the relative mapping densities of the magno- and parvocellular systems vary with eccentricity? J Neurosci 8:4334-9
Livingstone, M S; Hubel, D H (1987) Connections between layer 4B of area 17 and the thick cytochrome oxidase stripes of area 18 in the squirrel monkey. J Neurosci 7:3371-7
Livingstone, M S; Hubel, D H (1987) Psychophysical evidence for separate channels for the perception of form, color, movement, and depth. J Neurosci 7:3416-68
Carlson, M; Hubel, D H; Wiesel, T N (1986) Effects of monocular exposure to oriented lines on monkey striate cortex. Brain Res 390:71-81
Hubel, D H; Livingstone, M S (1985) Complex-unoriented cells in a subregion of primate area 18. Nature 315:325-7