The proposed research will study the circulatory system which has evolved to nourish and to protect the transparent and neural structures of the eye. Methods will be employed to measure the rate of flow of aqueous humor in the human eye, methods which depend on fluorescent tracers and which are independent of pressure, resistance, or the stress-strain relations of the eye. Flow will be studied in human eyes to determine what role it plays in the intact eye in the regulation of intraocular pressure and how flow itself can be regulated. New techniques employing fluorescent probes are proposed to measure pH, oxygen concentration, and colloid concentration in the cornea and the anterior chamber. Studies of a number of clinical disorders will be carried out both to reveal the ocular adaptations to the disease and to characterize the disease. The conditions to be studied are unilateral Horner's syndrome, unilateral carotid occlusion, open angle glaucoma, ocular hypertension, low tension glaucoma, uveitis, and pigmentary glaucoma. The effects of adrenergic drugs on aqueous humor and other drugs whose effects are mediated by cAMP will be studied.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY000634-17
Application #
3255476
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1976-03-01
Project End
1989-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
17
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
McLaren, Jay W; Herman, David C; Brubaker, Richard F et al. (2003) Effect of ibopamine on aqueous humor production in normotensive humans. Invest Ophthalmol Vis Sci 44:4853-8
Leavitt, Jacqueline A; Wayman, Laura L; Hodge, David O et al. (2002) Pupillary response to four concentrations of pilocarpine in normal subjects: application to testing for Adie tonic pupil. Am J Ophthalmol 133:333-6
Brubaker, R F; Schoff, E O; Nau, C B et al. (2001) Effects of AGN 192024, a new ocular hypotensive agent, on aqueous dynamics. Am J Ophthalmol 131:19-24
Brubaker, R F; Ingram, C J; Schoff, E O et al. (2000) Comparison of the efficacy of betaxolol-brinzolamide and timolol-dorzolamide as suppressors of aqueous humor flow in human subjects. Ophthalmology 107:283-7
Brubaker, R F; Bourne, W M; Bachman, L A et al. (2000) Ascorbic acid content of human corneal epithelium. Invest Ophthalmol Vis Sci 41:1681-3
Maus, T L; Brubaker, R F (1999) Measurement of aqueous humor flow by fluorophotometry in the presence of a dilated pupil. Invest Ophthalmol Vis Sci 40:542-6
McLaren, J W; Bachman, L A; Brubaker, R F (1999) Comparison of effects of topical ibopamine and epinephrine on the circadian rhythm of intraocular pressure of the rabbit eye as measured by telemetry. J Ocul Pharmacol Ther 15:107-16
Ingram, C J; Brubaker, R F (1999) Effect of brinzolamide and dorzolamide on aqueous humor flow in human eyes. Am J Ophthalmol 128:292-6
Maus, T L; Nau, C; Brubaker, R F (1999) Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents. Arch Ophthalmol 117:586-91
Vanlandingham, B D; FitzSimon, J S; Brubaker, R F (1998) Aqueous humor flow in sleeping humans is unaffected by norepinephrine infusion. Invest Ophthalmol Vis Sci 39:1759-62

Showing the most recent 10 out of 87 publications