Abstract

Open-angle glaucoma (OAG) afflicts 2% of the population over 40 years of age. Its etiology and the factors responsible for its progression are unknown. The ultimate objective of this project is to determine the mechanisms responsible for the malfunction of the aqueous outflow pathways in glaucoma. Our hypothesis is that major tissue alterations afflict the trabecular meshwork in Primary Open-Angle Glaucoma. We will examine glucoma specimens and compare them with age-matched normals using new quntitative as well as qualitataive methods. Our hypothesis will be further tested by analysing connective tissues changes in the outflow pathways of secondary open-angle glaucoma and in experimental studies to better define the relationship of cell loss and connective tissue change.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002068-12
Application #
3256482
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1977-08-01
Project End
1991-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
12
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Underwood, J L; Murphy, C G; Chen, J et al. (1999) Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions. Am J Physiol 277:C330-42
Alvarado, J A; Murphy, C G; Franse-Carman, L et al. (1998) Effect of beta-adrenergic agonists on paracellular width and fluid flow across outflow pathway cells. Invest Ophthalmol Vis Sci 39:1813-22
Chen, J; Cohn, R A; Lin, S C et al. (1997) Endoscopic photocoagulation of the ciliary body for treatment of refractory glaucomas. Am J Ophthalmol 124:787-96
Butler, P; Mannschreck, M; Lin, S et al. (1995) Clinical experience with the long-term use of 1% apraclonidine. Incidence of allergic reactions. Arch Ophthalmol 113:293-6
Crook, R B; Lui, G M; Alvarado, J A et al. (1994) High affinity vasoactive intestinal peptide receptors on fetal human nonpigmented ciliary epithelial cells. Curr Eye Res 13:271-9
Alvarado, J A; Underwood, J L; Green, W R et al. (1994) Detection of herpes simplex viral DNA in the iridocorneal endothelial syndrome. Arch Ophthalmol 112:1601-9
Alvarado, J A; Murphy, C G (1992) Outflow obstruction in pigmentary and primary open angle glaucoma. Arch Ophthalmol 110:1769-78
Murphy, C G; Johnson, M; Alvarado, J A (1992) Juxtacanalicular tissue in pigmentary and primary open angle glaucoma. The hydrodynamic role of pigment and other constituents. Arch Ophthalmol 110:1779-85
Alvarado, J A; Franse-Carman, L; McHolm, G et al. (1990) Epinephrine effects on major cell types of the aqueous outflow pathway: in vitro studies/clinical implications. Trans Am Ophthalmol Soc 88:267-82;discussion 283-8
Yun, A J; Murphy, C G; Polansky, J R et al. (1989) Proteins secreted by human trabecular cells. Glucocorticoid and other effects. Invest Ophthalmol Vis Sci 30:2012-22

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