Abstract

The goal of this research project is to understand the transport mechanism(s) by which the pigment epithelium (PE) interacts with and supports the normal functioning of the neural retina and the choroidal blood supply. One way the PE does this is by actively mintaining the chemical milieu of the retinal and choroidal spaces. When this ability is lost, for example, by disease of the pigment epithelium, the retina dies and vision may be lost.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002205-08
Application #
3256581
Study Section
(VID)
Project Start
1978-02-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
Schools of Optometry/Opht Tech
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Voloboueva, Ludmila A; Killilea, David W; Atamna, Hani et al. (2007) N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. FASEB J 21:4077-86
Voloboueva, Ludmila A; Liu, Jiankang; Suh, Jung H et al. (2005) (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Invest Ophthalmol Vis Sci 46:4302-10
Liou, Gregory I; Samuel, Sara; Matragoon, Suraporn et al. (2004) Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium. Mol Vis 10:383-91
Wang, Fei; Rendahl, Katherine G; Manning, William C et al. (2003) AAV-mediated expression of vascular endothelial growth factor induces choroidal neovascularization in rat. Invest Ophthalmol Vis Sci 44:781-90
Maminishkis, Arvydas; Jalickee, Stephen; Blaug, Sasha A et al. (2002) The P2Y(2) receptor agonist INS37217 stimulates RPE fluid transport in vitro and retinal reattachment in rat. Invest Ophthalmol Vis Sci 43:3555-66
Quinn, R H; Quong, J N; Miller, S S (2001) Adrenergic receptor activated ion transport in human fetal retinal pigment epithelium. Invest Ophthalmol Vis Sci 42:255-64
Rymer, J; Miller, S S; Edelman, J L (2001) Epinephrine-induced increases in [Ca2+](in) and KCl-coupled fluid absorption in bovine RPE. Invest Ophthalmol Vis Sci 42:1921-9
Uyekubo, S N; Fischer, H; Maminishkis, A et al. (1998) cAMP-dependent absorption of chloride across airway epithelium. Am J Physiol 275:L1219-27
Kenyon, E; Maminishkis, A; Joseph, D P et al. (1997) Apical and basolateral membrane mechanisms that regulate pHi in bovine retinal pigment epithelium. Am J Physiol 273:C456-72
Peterson, W M; Meggyesy, C; Yu, K et al. (1997) Extracellular ATP activates calcium signaling, ion, and fluid transport in retinal pigment epithelium. J Neurosci 17:2324-37

Showing the most recent 10 out of 34 publications