Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY002566-17
Application #
2158453
Study Section
Visual Sciences C Study Section (VISC)
Project Start
1978-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
17
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Wayne State University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Frank, R N; Amin, R H; Puklin, J E (1999) Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. Am J Ophthalmol 127:694-709
Frank, R N (1998) ""Oxidative protector"" enzymes in the macular retinal pigment epithelium of aging eyes and eyes with age-related macular degeneration. Trans Am Ophthalmol Soc 96:635-89
Amin, R H; Frank, R N; Kennedy, A et al. (1997) Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 38:36-47
Frank, R N; Amin, R; Kennedy, A et al. (1997) An aldose reductase inhibitor and aminoguanidine prevent vascular endothelial growth factor expression in rats with long-term galactosemia. Arch Ophthalmol 115:1036-47
Frank, R N (1997) Growth factors in age-related macular degeneration: pathogenic and therapeutic implications. Ophthalmic Res 29:341-53
Frank, R N; Amin, R H; Eliott, D et al. (1996) Basic fibroblast growth factor and vascular endothelial growth factor are present in epiretinal and choroidal neovascular membranes. Am J Ophthalmol 122:393-403
Amin, R; Puklin, J E; Frank, R N (1994) Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. Invest Ophthalmol Vis Sci 35:3178-88
Frank, R N (1994) The aldose reductase controversy. Diabetes 43:169-72
Das, A; Puklin, J E; Frank, R N et al. (1992) Ultrastructural immunocytochemistry of subretinal neovascular membranes in age-related macular degeneration. Ophthalmology 99:1368-76
Frank, R N (1991) On the pathogenesis of diabetic retinopathy. A 1990 update. Ophthalmology 98:586-93

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