Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
2R01EY002715-10
Application #
3257088
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1979-01-01
Project End
1988-06-30
Budget Start
1988-04-01
Budget End
1988-06-30
Support Year
10
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Children's Hospital of Los Angeles
Department
Type
DUNS #
094878337
City
Los Angeles
State
CA
Country
United States
Zip Code
90027
Xu, H J; Sumegi, J; Hu, S X et al. (1991) Intraocular tumor formation of RB reconstituted retinoblastoma cells. Cancer Res 51:4481-5
Ishikawa, J; Xu, H J; Hu, S X et al. (1991) Inactivation of the retinoblastoma gene in human bladder and renal cell carcinomas. Cancer Res 51:5736-43
Oka, K; Ishikawa, J; Bruner, J M et al. (1991) Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and bladder cancer using the polymerase chain reaction. Mol Carcinog 4:10-3
Takahashi, R; Hashimoto, T; Xu, H J et al. (1991) The retinoblastoma gene functions as a growth and tumor suppressor in human bladder carcinoma cells. Proc Natl Acad Sci U S A 88:5257-61
Xu, H J; Hu, S X; Benedict, W F (1991) Lack of nuclear RB protein staining in G0/middle G1 cells: correlation to changes in total RB protein level. Oncogene 6:1139-46
Xu, H J; Hu, S X; Cagle, P T et al. (1991) Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res 51:2735-9
Hashimoto, T; Takahashi, R; Yandell, D W et al. (1991) Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression. Oncogene 6:463-9
Benedict, W F; Xu, H J; Hu, S X et al. (1990) Role of the retinoblastoma gene in the initiation and progression of human cancer. J Clin Invest 85:988-93
Benedict, W F; Xu, H J; Takahashi, R (1990) The retinoblastoma gene: its role in human malignancies. Cancer Invest 8:535-40
Leach, R J; Magewu, A N; Buckley, J D et al. (1990) Preferential retention of paternal alleles in human retinoblastoma: evidence for genomic imprinting. Cell Growth Differ 1:401-6

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