Abstract

We will continue our work on membrane circulation in nervous tissue, especially on the photoreceptors of the frog retina. Studies will concern: 1. lipid synthesis in rod cells as detectable by electron microscope autoradiography; 2. the influence of various divalent cations on membrane circulation in photoreceptor presynaptic terminals; 3) the uptake and sequestering of Ca2 ion by rod cell endoplasmic reticulum; 4. the uptake of peroxidase labeled cholera toxin by photoreceptors; 5. the properties of peroxisomes in nervous tissue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003168-18
Application #
3257437
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1979-09-01
Project End
1988-09-29
Budget Start
1987-09-30
Budget End
1988-09-29
Support Year
18
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Graduate Schools
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Augenbraun, E; Maxfield, F R; St Jules, R et al. (1993) Properties of acidified compartments in hippocampal neurons. Eur J Cell Biol 61:34-43
St Jules, R; Kennard, J; Setlik, W et al. (1992) Frog cones as well as Muller cells have peroxisomes. Exp Eye Res 54:1-8
Beard, M E (1990) D-aspartate oxidation by rat and bovine renal peroxisomes: an electron microscopic cytochemical study. J Histochem Cytochem 38:1377-81
Augenbraun, E; Sulzer, D; Rayport, S et al. (1990) Experiments on the use of DAMP to study retina and cultured neurons. J Histochem Cytochem 38:1927-31
St Jules, R; Setlik, W; Kennard, J et al. (1990) Peroxisomes in the head of Drosophila melanogaster. Exp Eye Res 51:607-17
Sulzer, D; Ungar, F; Holtzman, E (1990) Further studies on the cationic staining of retinal photoreceptors. J Histochem Cytochem 38:743-5
Czajkowski, C; DiPaola, M; Bodkin, M et al. (1989) The intactness and orientation of acetylcholine receptor-rich membrane from Torpedo californica electric tissue. Arch Biochem Biophys 272:412-20
Sulzer, D; Holtzman, E (1989) Acidification and endosome-like compartments in the presynaptic terminals of frog retinal photoreceptors. J Neurocytol 18:529-40
Beard, M E; Davies, T; Holloway, M et al. (1988) Peroxisomes in pigment epithelium and Muller cells of amphibian retina possess D-amino acid oxidase as well as catalase. Exp Eye Res 47:795-806
Naidu, S; Hoefler, G; Watkins, P A et al. (1988) Neonatal seizures and retardation in a girl with biochemical features of X-linked adrenoleukodystrophy: a possible new peroxisomal disease entity. Neurology 38:1100-7

Showing the most recent 10 out of 18 publications