This research combines engineering programs at Riverside Research Institute (RRI) and medical programs at Cornell University Medical College (CUMC) to study the alterations which can be induced in ocular tissues by high intensity ultrasound. The objective of the research is to provide the knowledge and practical means for applying ultrasound as a therapeutic modality in ophthalmology. A therapeutic ultrasound system will be used to provide stable repeatable exposures over well-defined tissue volumes. It will be coupled with diagnostic ultrasound visualization systems to enable accurate exposure of target tissues regardless of the optical status of the media. Therapeutic applications will be investigated on in vitro and in vivo animal models as a prelude to human insonification. The potential for this modality in treatment of ophthalmic disorders includes disruption and dispersion of vitreous hemorrhages and membranes, creation of chorioretinal lesions to confine retinal tears, destruction of ocular tumors and treatment of refractory glaucoma. The effect of intense ultrasound on tissues will be studied by indirect ophthalmoscopy, fundus photography and diagnostic ultrasonography, and histologically by light, electron, and acoustic microscopy. Knowledge gained concerning fundamental mechanisms of tissue-ultrasound interactions will insure the safety of the intended therapies. RRI's efforts under its grant involve engineering, computer, and analytic studies as well as the design and construction of ultrasound systems, which will be used by qualified medical personnel at CUMC under its separate collaborative, grant.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003174-11
Application #
3257457
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1979-04-01
Project End
1991-06-30
Budget Start
1989-07-01
Budget End
1990-06-30
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Polack, P J; Iwamoto, T; Silverman, R H et al. (1991) Histologic effects of contact ultrasound for the treatment of glaucoma. Invest Ophthalmol Vis Sci 32:2136-42
Rutzen, A R; Roberts, C W; Driller, J et al. (1990) Production of corneal lesions using high-intensity focused ultrasound. Cornea 9:324-30
Lucas, B C; Driller, J; Iwamoto, T et al. (1989) Ultrasonically induced disruption and hemolysis of vitreous hemorrhages. Ultrasound Med Biol 15:29-37
Coleman, D J; Silverman, R H; Iwamoto, T et al. (1988) Histopathologic effects of ultrasonically induced hyperthermia in intraocular malignant melanoma. Ophthalmology 95:970-81
Lizzi, F L; Ostromogilsky, M (1987) Analytical modelling of ultrasonically induced tissue heating. Ultrasound Med Biol 13:607-18
Burgess, S E; Iwamoto, T; Coleman, D J et al. (1987) Histologic changes in porcine eyes treated with high-intensity focused ultrasound. Ann Ophthalmol 19:133-8
Riedel, K G; Svitra, P P; Albert, D M et al. (1986) [Combined hyperthermia and proton irradiation: a new method in the treatment of malignant melanoma of the choroid?] Fortschr Ophthalmol 83:483-8
Coleman, D J; Lizzi, F L; Silverman, R H et al. (1986) Therapeutic ultrasound. Ultrasound Med Biol 12:633-8
Coleman, D J; Lizzi, F L; Burgess, S E et al. (1986) Ultrasonic hyperthermia and radiation in the management of intraocular malignant melanoma. Am J Ophthalmol 101:635-42
Silverman, R H; Coleman, D J; Lizzi, F L et al. (1986) Ultrasonic tissue characterization and histopathology in tumor xenografts following ultrasonically induced hyperthermia. Ultrasound Med Biol 12:639-45

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