Abstract

Clinical and animal studies of eyes with hypotony will be performed to evaluate the mechanisms of hypotony. Experimental models of ciliochoroidal detachment, retinal detachment, and cyclodialysis in monkeys have been developed which result in hypotony. Aqueous flow studies and vitreous flow studies will be performed in these models by use of radioisotope tracers and fluorophotometry. In addition, aqueous flow by flurophotometry will be measured in cases of hypotony. A drug combination of methacholine plus eserine has been shown to reverse experimental hypotony by reducing uvecscleral aqueous outflow. Additional drugs will be investigated for potential use in the treatment of ocular hypotony.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY003277-07
Application #
3257585
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1979-07-01
Project End
1987-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Toris, C B; Pederson, J E; Tsuboi, S et al. (1990) Extravascular albumin concentration of the uvea. Invest Ophthalmol Vis Sci 31:43-53
Emi, K; Pederson, J E; Toris, C B (1989) Hydrostatic pressure of the suprachoroidal space. Invest Ophthalmol Vis Sci 30:233-8
Tsuboi, S; Pederson, J E (1988) Volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes. Invest Ophthalmol Vis Sci 29:1652-5
Tsuboi, S; Pederson, J E (1988) Effect of plasma osmolality and intraocular pressure on fluid movement across the blood-retinal barrier. Invest Ophthalmol Vis Sci 29:1747-9
Tsuboi, S; Pederson, J E (1987) Acetazolamide effect on the inward permeability of the blood-retinal barrier to carboxyfluorescein. Invest Ophthalmol Vis Sci 28:92-5
Tsuboi, S; Pederson, J E (1987) Permeability of the blood-retinal barrier to carboxyfluorescein in eyes with rhegmatogenous retinal detachment. Invest Ophthalmol Vis Sci 28:96-100
Toris, C B; Pederson, J E (1987) Aqueous humor dynamics in experimental iridocyclitis. Invest Ophthalmol Vis Sci 28:477-81
Toris, C B; Gregerson, D S; Pederson, J E (1987) Uveoscleral outflow using different-sized fluorescent tracers in normal and inflamed eyes. Exp Eye Res 45:525-32
Pederson, J E; Toris, C B (1987) Uveoscleral outflow: diffusion or flow? Invest Ophthalmol Vis Sci 28:1022-4
Tsuboi, S; Pederson, J E; Toris, C B (1987) Functional recovery of retinal pigment epithelial damage in experimental retinal detachment. Invest Ophthalmol Vis Sci 28:1788-94

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