Abstract

The objective of this project is to increase utilization of the Registry of Ophthalmic Pathology, its professional staff, and the unique facilities of the Armed Forces Institute of Pathology for improvement in diagnosis and management of ophthalmic diseases. Utilizing currently accepted diagnostic criteria, terminology and classification, cases of value for teaching and research purposes will be re-evaluated and all pertinent clinical, pathologic and follow-up data will be computerized so that the exceedingly abundant material can be made readily available for investigative work. Major emphasis will be placed on those conditions for which the Registry material is exceptionally abundant, well documented, and pertinent to problems of current clinical interest. Efforts will be made to improve histopathologic diagnosis and prognosis by application of the most helpful adjunctive methods including histochemistry, electron microscopy, immunoperoxidase microscopy, etc. Long term follow-up data will be used to check on the accuracy of histopathologic diagnosis and the efficacy of various methods of treatment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY004482-05
Application #
3258939
Study Section
(VID)
Project Start
1982-02-01
Project End
1987-06-30
Budget Start
1986-01-01
Budget End
1987-06-30
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
American Registry of Pathology, Inc.
Department
Type
DUNS #
114400633
City
Washington
State
DC
Country
United States
Zip Code
20306

  Publications

Specht, C S; McLean, I W; Biscoe, B W (1990) Traumatic enucleation for posterior uveal melanoma. Am J Ophthalmol 110:518-21
McLean, I W; Berd, D; Mastrangelo, M J et al. (1990) A randomized study of methanol-extraction residue of bacille Calmette-Guerin as postsurgical adjuvant therapy of uveal melanoma. Am J Ophthalmol 110:522-6
Memmen, J E; McLean, I W (1990) The long-term outcome of patients undergoing iridocyclectomy. Ophthalmology 97:429-32
de la Cruz Jr, P O; Specht, C S; McLean, I W (1990) Lymphocytic infiltration in uveal malignant melanoma. Cancer 65:112-5
Huntington, A; Haugan, P; Gamel, J et al. (1989) A simple cytologic method for predicting the malignant potential of intraocular melanoma. Pathol Res Pract 185:631-4
McLean, I W; Gamel, J W (1988) Prediction of metastasis of uveal melanoma: comparison of morphometric determination of nucleolar size and spectrophotometric determination of DNA. Invest Ophthalmol Vis Sci 29:507-11
Bardenstein, D S; McLean, I W; Nerney, J et al. (1988) Cowden's disease. Ophthalmology 95:1038-41
Gamel, J W; Greenberg, R A; McLean, I W (1988) A stable linear algorithm for fitting the lognormal model to survival data. Comput Biomed Res 21:38-47
Gamel, J W; McLean, I W; Greenberg, R A (1988) Interval-by-interval Cox model analysis of 3680 cases of intraocular melanoma shows a decline in the prognostic value of size and cell type over time after tumor excision. Cancer 61:574-9
Roarty, J D; McLean, I W; Zimmerman, L E (1988) Incidence of second neoplasms in patients with bilateral retinoblastoma. Ophthalmology 95:1583-7

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