Experiments are directed at identifying biochemical events in the teleost retinal ganglion cell that mediate regrowth of the optic nerve and lead to recovery of visual function. The nature of altered radiolabeling of axonally transported proteins, including tubulin, as well as glycerolipids, terpenes and nucleotides will be investigated. A major effort is directed at biochemical characterization of explanted retinal cultures, as well as single ganglion cells and elucidation of the mechanism of enhanced outgrowth of neurites which results from prior crush of the optic nerve. These studies are directed at a better understanding of nerve regeneration in general, and in particular, as it appears within the central nervous system of both lower and higher vertebrates.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY005947-09
Application #
3261691
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1977-04-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
9
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Cauley, K; Agranoff, B W; Goldman, D (1989) Identification of a novel nicotinic acetylcholine receptor structural subunit expressed in goldfish retina. J Cell Biol 108:637-45
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