The objective of this research is to develop and study nonhuman primate models of strabismus. Four specific monkey models are proposed: 1) surgical, 2) optical, 3) neurotoxin, and 4) natural. Each monkey model will be tested behaviorally to determine what impairments in visual functions result from the strabismus. Specific impairments to the looked for are amblyopia and loss of binocular stereoscopic vision. Experiments are designed to determine both the magnitude of any impairments and also the time course over which they develop. These measurements will be used to provide information about the """"""""sensitive period"""""""" associated with strabismus. Macaque monkeys are chosen as the model species because information about sensitive periods can be extrapolated to humans with more confidence than from any non primate model.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
3R01EY006436-02S1
Application #
3262513
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1985-09-01
Project End
1987-06-30
Budget Start
1986-03-01
Budget End
1987-06-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Emory University
Department
Type
Primate Centers
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Quick, M W; Newbern, J D; Boothe, R G (1994) Natural strabismus in monkeys: accommodative errors assessed by photorefraction and their relationship to convergence errors. Invest Ophthalmol Vis Sci 35:4069-79
Quick, M W; Eggers, H M; Boothe, R G (1992) Natural strabismus in monkeys. Convergence errors assessed by cover test and photographic methods. Invest Ophthalmol Vis Sci 33:2986-3004
Quick, M W; Boothe, R G (1989) Measurement of binocular alignment in normal monkeys and in monkeys with strabismus. Invest Ophthalmol Vis Sci 30:1159-68