Can the binocular vision prognosis in infantile esotropia be improved beyond the monofixation or worse outcome typically achieved with current detection and treatment methods? Can manifestation of the deviation be prevented to begin with? The present (revised) proposal will investigate the hypothesis that there are """"""""precursor"""""""" sensory and/or oculomotor states prior to the onset of infantile esotropia which may provide the basis for affirmative answers to these questions.l The proposed study will be longitudinal in design, comprised of initial binocular vision, motor and refractive measurements in at least 825 4 to 24 week old infants at normal or high risk for esotropia, and then follow-up one and two years later to determine if esotropia has developed. Our hypothesis is that there will be a difference in one or a combination of the early measures between the population of infants who develop esotropia and those who do not. Binocular vision tests include measurement of peripheral fusion by dynamic random dot """"""""fusiogram"""""""" or """"""""aniseikoniagram,"""""""" and stereoacuity by dynamic random dot stereogram. Eye movements will be the response measure, and eye tracking records will also be analyzed for oculomotor anomalies that may themselves constitute esotropia precursors. All study participants will receive a full clinical examination, including cycloplegic retinoscopy.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY007577-03
Application #
3264609
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1990-04-01
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Simons, K; Gotzler, K C; Vitale, S (1997) Penalization versus part-time occlusion and binocular outcome in treatment of strabismic amblyopia. Ophthalmology 104:2156-60
Simons, K; Stein, L; Sener, E C et al. (1997) Full-time atropine, intermittent atropine, and optical penalization and binocular outcome in treatment of strabismic amblyopia. Ophthalmology 104:2143-55
Simons, K (1996) Preschool vision screening: rationale, methodology and outcome. Surv Ophthalmol 41:3-30
Simons, K; Avery, K E; Novak, A (1996) Small-target random dot stereogram and binocular suppression testing for preschool vision screening. J Pediatr Ophthalmol Strabismus 33:104-13
Simons, K; Arnoldi, K; Brown, M H (1994) Color dissociation artifacts in double Maddox rod cyclodeviation testing. Ophthalmology 101:1897-901
Simons, K; Elhatton, K (1994) Artifacts in fusion and stereopsis testing based on red/green dichoptic image separation. J Pediatr Ophthalmol Strabismus 31:290-7
Miller, J M; Mellinger, M; Greivenkemp, J et al. (1993) Videographic Hirschberg measurement of simulated strabismic deviations. Invest Ophthalmol Vis Sci 34:3220-9